Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1

Structural basis for autoinhibition by the dephosphorylated regulatory domain of Ycf1

Abstract Yeast Cadmium Factor 1 (Ycf1) sequesters glutathione and glutathione-heavy metal conjugates into yeast vacuoles as a cellular detoxification mechanism. Ycf1 belongs to the C subfamily of ATP Binding Cassette (ABC) transporters characterized by long flexible linkers, notably the regulatory d...

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Bibliographic Details
Main Authors: Nitesh Kumar Khandelwal, Thomas M. Tomasiak
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46722-w

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