Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas
Due to the special physiological and pathological characteristics of gliomas, most therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of existing therapies, researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383521003038 |
| _version_ | 1818394189412433920 |
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| author | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang |
| author_facet | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang |
| author_sort | Jiwei Cui |
| collection | DOAJ |
| description | Due to the special physiological and pathological characteristics of gliomas, most therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of existing therapies, researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy. Although these strategies can be used clinically to overcome the blood‒brain barrier (BBB), the accurate delivery of drugs to the glioma lesions cannot be ensured. Nano-drug delivery systems (NDDS) have been widely used for precise drug delivery. In recent years, researchers have gathered their wisdom to overcome barriers, so many well-designed NDDS have performed prominently in preclinical studies. These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions, drug release in response to the glioma microenvironment, biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein, and carriers created according to the active ingredients of traditional Chinese medicines. We reviewed these well-designed NDDS in detail. Furthermore, we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy, and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. |
| first_indexed | 2024-12-14T05:57:15Z |
| format | Article |
| id | doaj.art-68224d0ddb79409495ce4c4d98b223ec |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-14T05:57:15Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-68224d0ddb79409495ce4c4d98b223ec2022-12-21T23:14:32ZengElsevierActa Pharmaceutica Sinica B2211-38352022-03-0112311001125Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomasJiwei Cui0Yuanxin Xu1Haiyan Tu2Huacong Zhao3Honglan Wang4Liuqing Di5Ruoning Wang6College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology, Research Center of High Efficient Drug Delivery System, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology, Research Center of High Efficient Drug Delivery System, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology, Research Center of High Efficient Drug Delivery System, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology, Research Center of High Efficient Drug Delivery System, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology, Research Center of High Efficient Drug Delivery System, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology, Research Center of High Efficient Drug Delivery System, Nanjing 210023, ChinaCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology, Research Center of High Efficient Drug Delivery System, Nanjing 210023, China; Corresponding author. Tel./fax: +86 15852937869.Due to the special physiological and pathological characteristics of gliomas, most therapeutic drugs are prevented from entering the brain. To improve the poor prognosis of existing therapies, researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy. Although these strategies can be used clinically to overcome the blood‒brain barrier (BBB), the accurate delivery of drugs to the glioma lesions cannot be ensured. Nano-drug delivery systems (NDDS) have been widely used for precise drug delivery. In recent years, researchers have gathered their wisdom to overcome barriers, so many well-designed NDDS have performed prominently in preclinical studies. These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions, drug release in response to the glioma microenvironment, biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein, and carriers created according to the active ingredients of traditional Chinese medicines. We reviewed these well-designed NDDS in detail. Furthermore, we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy, and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS.http://www.sciencedirect.com/science/article/pii/S2211383521003038GliomaBlood‒brain barrierNon-invasive strategiesNano-drug delivery systemsCascade targetingResponsive delivery and release |
| spellingShingle | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas Acta Pharmaceutica Sinica B Glioma Blood‒brain barrier Non-invasive strategies Nano-drug delivery systems Cascade targeting Responsive delivery and release |
| title | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
| title_full | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
| title_fullStr | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
| title_full_unstemmed | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
| title_short | Gather wisdom to overcome barriers: Well-designed nano-drug delivery systems for treating gliomas |
| title_sort | gather wisdom to overcome barriers well designed nano drug delivery systems for treating gliomas |
| topic | Glioma Blood‒brain barrier Non-invasive strategies Nano-drug delivery systems Cascade targeting Responsive delivery and release |
| url | http://www.sciencedirect.com/science/article/pii/S2211383521003038 |
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