PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine.
Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensiv...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4640719?pdf=render |
| _version_ | 1811273312566771712 |
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| author | Ji-Hyun Lee Kyoung Mii Park Dong-Jin Han Nam Young Bang Do-Hee Kim Hyeongjin Na Semi Lim Tae Bum Kim Dae Gyu Kim Hyun-Jung Kim Yeonseok Chung Sang Hyun Sung Young-Joon Surh Sunghoon Kim Byung Woo Han |
| author_facet | Ji-Hyun Lee Kyoung Mii Park Dong-Jin Han Nam Young Bang Do-Hee Kim Hyeongjin Na Semi Lim Tae Bum Kim Dae Gyu Kim Hyun-Jung Kim Yeonseok Chung Sang Hyun Sung Young-Joon Surh Sunghoon Kim Byung Woo Han |
| author_sort | Ji-Hyun Lee |
| collection | DOAJ |
| description | Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org. |
| first_indexed | 2024-04-12T22:55:42Z |
| format | Article |
| id | doaj.art-68239d1c63fa4bebb1266688438f318f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T22:55:42Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-68239d1c63fa4bebb1266688438f318f2022-12-22T03:13:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014262410.1371/journal.pone.0142624PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine.Ji-Hyun LeeKyoung Mii ParkDong-Jin HanNam Young BangDo-Hee KimHyeongjin NaSemi LimTae Bum KimDae Gyu KimHyun-Jung KimYeonseok ChungSang Hyun SungYoung-Joon SurhSunghoon KimByung Woo HanDespite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org.http://europepmc.org/articles/PMC4640719?pdf=render |
| spellingShingle | Ji-Hyun Lee Kyoung Mii Park Dong-Jin Han Nam Young Bang Do-Hee Kim Hyeongjin Na Semi Lim Tae Bum Kim Dae Gyu Kim Hyun-Jung Kim Yeonseok Chung Sang Hyun Sung Young-Joon Surh Sunghoon Kim Byung Woo Han PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. PLoS ONE |
| title | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. |
| title_full | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. |
| title_fullStr | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. |
| title_full_unstemmed | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. |
| title_short | PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine. |
| title_sort | pharmdb k integrated bio pharmacological network database for traditional korean medicine |
| url | http://europepmc.org/articles/PMC4640719?pdf=render |
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