血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study
目的 研究血清脂蛋白相关磷脂酶A2（1ipoprotein-associated phospholipase A2，Lp-PLA2）水平对颈动 脉粥样硬化斑块及其稳定性的预测价值。 方法 本研究患者来源于无症状性多血管床狭窄的社区研究 (A s y m p t o m at i c P o l y v a s c u l a r Abnormalities Community，APAC)。检测入组患者血清Lp-PLA2水平，通过超声评估颈动脉粥样硬化斑块 特点。按照血清Lp-PLA2水平的四分位数，将受试者分为4组，用Logistic回归模型分析血清Lp-PLA2水 平与颈动脉粥样硬化斑块及斑...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Chinese Journal of Stroke
2019-09-01
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| Series: | Zhongguo cuzhong zazhi |
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| Online Access: | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=2855 |
| _version_ | 1818487181503627264 |
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| author | 申园，王丹丹，赵性泉 |
| author_facet | 申园，王丹丹，赵性泉 |
| author_sort | 申园，王丹丹，赵性泉 |
| collection | DOAJ |
| description | 目的 研究血清脂蛋白相关磷脂酶A2（1ipoprotein-associated phospholipase A2，Lp-PLA2）水平对颈动 脉粥样硬化斑块及其稳定性的预测价值。 方法 本研究患者来源于无症状性多血管床狭窄的社区研究 (A s y m p t o m at i c P o l y v a s c u l a r Abnormalities Community，APAC)。检测入组患者血清Lp-PLA2水平，通过超声评估颈动脉粥样硬化斑块 特点。按照血清Lp-PLA2水平的四分位数，将受试者分为4组，用Logistic回归模型分析血清Lp-PLA2水 平与颈动脉粥样硬化斑块及斑块稳定性的关系。 结果 高Lp-PLA2水平（＞159.1 ng/mL）是颈动脉不稳定斑块发生的预测因素（OR 2.8，95%CI 2.0～3.8，P <0.0001），在校正危险因素后，这种趋势没有发生变化（OR 1.7，95%CI 1.2～2.5，P＝ 0.0067），在＜60岁受试者中，该差异仍然存在（OR 1.7，95%CI 1.1～2.7，P =0.0142），但在≥60岁受试 者中，其预测价值未达到统计学意义。 结论 较高血清Lp-PLA2水平是颈动脉不稳定粥样硬化斑块发生的预测因素，尤其在＜60岁患者中。
Abstract:
Objective To investigate the association of serum total 1ipoprotein-associated phospholipase A2 (Lp-PLA2) level with the vulnerability of atherosclerotic carotid plaques. Methods Data of this cohort study were from Asymptomatic Polyvascular Abnormalities Community (APAC) study, which was a cross-sectional study. The data of serum Lp-PLA2 level and ultrasonographic assessment of carotid plaques were extracted and analyzed. The participants were divided into 4 groups based on the quartile of serum total Lp-PLA2 level. The multivariate logistic regression analysis was used to analyze the correlation between the serum total Lp-PLA2 level and carotid plaque development and vulnerability. Results A high Lp-PLA2 level (>159.1 ng/mL) was associated with carotid plaque vulnerability amongst the adults (OR 2.8, 95%CI 2.0-3.8, P <0.0001). After adjusting for the relevant risk factors, the tendency still existed (OR 1.7, 95%CI 1.2-2.5, P =0.0067). For subjects aged <60 years old, the correlation between the two variates still existed (OR 1.7, 95%CI 1.1-2.7, P =0.0142), while for subjects aged ≥60 years old, the difference of serum Lp-PLA2 level among the 4 groups had no statistical significance Conclusions An elevated serum Lp-PLA2 level was associated with carotid plaque vulnerability in adults, especially ones aged <60 years. |
| first_indexed | 2024-12-10T16:34:15Z |
| format | Article |
| id | doaj.art-6825931d3ed6414c9aaf6ba5404afc61 |
| institution | Directory Open Access Journal |
| issn | 1673-5765 |
| language | zho |
| last_indexed | 2024-12-10T16:34:15Z |
| publishDate | 2019-09-01 |
| publisher | Editorial Department of Chinese Journal of Stroke |
| record_format | Article |
| series | Zhongguo cuzhong zazhi |
| spelling | doaj.art-6825931d3ed6414c9aaf6ba5404afc612022-12-22T01:41:28ZzhoEditorial Department of Chinese Journal of StrokeZhongguo cuzhong zazhi1673-57652019-09-0114988288810.3969/j.issn.1673-5765.2019.09.006血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study申园，王丹丹，赵性泉0赵性泉 zxq@vip.163.com目的 研究血清脂蛋白相关磷脂酶A2（1ipoprotein-associated phospholipase A2，Lp-PLA2）水平对颈动 脉粥样硬化斑块及其稳定性的预测价值。 方法 本研究患者来源于无症状性多血管床狭窄的社区研究 (A s y m p t o m at i c P o l y v a s c u l a r Abnormalities Community，APAC)。检测入组患者血清Lp-PLA2水平，通过超声评估颈动脉粥样硬化斑块 特点。按照血清Lp-PLA2水平的四分位数，将受试者分为4组，用Logistic回归模型分析血清Lp-PLA2水 平与颈动脉粥样硬化斑块及斑块稳定性的关系。 结果 高Lp-PLA2水平（＞159.1 ng/mL）是颈动脉不稳定斑块发生的预测因素（OR 2.8，95%CI 2.0～3.8，P <0.0001），在校正危险因素后，这种趋势没有发生变化（OR 1.7，95%CI 1.2～2.5，P＝ 0.0067），在＜60岁受试者中，该差异仍然存在（OR 1.7，95%CI 1.1～2.7，P =0.0142），但在≥60岁受试 者中，其预测价值未达到统计学意义。 结论 较高血清Lp-PLA2水平是颈动脉不稳定粥样硬化斑块发生的预测因素，尤其在＜60岁患者中。 Abstract: Objective To investigate the association of serum total 1ipoprotein-associated phospholipase A2 (Lp-PLA2) level with the vulnerability of atherosclerotic carotid plaques. Methods Data of this cohort study were from Asymptomatic Polyvascular Abnormalities Community (APAC) study, which was a cross-sectional study. The data of serum Lp-PLA2 level and ultrasonographic assessment of carotid plaques were extracted and analyzed. The participants were divided into 4 groups based on the quartile of serum total Lp-PLA2 level. The multivariate logistic regression analysis was used to analyze the correlation between the serum total Lp-PLA2 level and carotid plaque development and vulnerability. Results A high Lp-PLA2 level (>159.1 ng/mL) was associated with carotid plaque vulnerability amongst the adults (OR 2.8, 95%CI 2.0-3.8, P <0.0001). After adjusting for the relevant risk factors, the tendency still existed (OR 1.7, 95%CI 1.2-2.5, P =0.0067). For subjects aged <60 years old, the correlation between the two variates still existed (OR 1.7, 95%CI 1.1-2.7, P =0.0142), while for subjects aged ≥60 years old, the difference of serum Lp-PLA2 level among the 4 groups had no statistical significance Conclusions An elevated serum Lp-PLA2 level was associated with carotid plaque vulnerability in adults, especially ones aged <60 years.http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=2855脂蛋白相关磷脂酶a2颈动脉动脉粥样硬化斑块危险因素lipoprotein-associated phospholipase a2carotid arteryatherosclerosis plaque;risk factor |
| spellingShingle | 申园，王丹丹，赵性泉 血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study Zhongguo cuzhong zazhi 脂蛋白相关磷脂酶a2 颈动脉 动脉粥样硬化斑块 危险因素 lipoprotein-associated phospholipase a2 carotid artery atherosclerosis plaque;risk factor |
| title | 血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study |
| title_full | 血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study |
| title_fullStr | 血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study |
| title_full_unstemmed | 血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study |
| title_short | 血清脂蛋白相关磷脂酶A2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 Association between Serum Lipoprotein-associated Phospholipase A2 Level and Carotid Plaque Development and Vulnerability: a Cross-sectional Study |
| title_sort | 血清脂蛋白相关磷脂酶a2水平对颈动脉粥样硬化斑块及其稳定性预测价值的研究 association between serum lipoprotein associated phospholipase a2 level and carotid plaque development and vulnerability a cross sectional study |
| topic | 脂蛋白相关磷脂酶a2 颈动脉 动脉粥样硬化斑块 危险因素 lipoprotein-associated phospholipase a2 carotid artery atherosclerosis plaque;risk factor |
| url | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=2855 |
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