Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm
The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2−/− mice exhibit m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211546314000400 |
| _version_ | 1818340110974844928 |
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| author | Lili Guo Deanna J. Volle Robert E. Lewis |
| author_facet | Lili Guo Deanna J. Volle Robert E. Lewis |
| author_sort | Lili Guo |
| collection | DOAJ |
| description | The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2−/− mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility. |
| first_indexed | 2024-12-13T15:37:42Z |
| format | Article |
| id | doaj.art-6825f86435e944ae894794c97d01eef7 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-12-13T15:37:42Z |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-6825f86435e944ae894794c97d01eef72022-12-21T23:39:58ZengWileyFEBS Open Bio2211-54632014-01-014C42042510.1016/j.fob.2014.04.004Identification of a truncated kinase suppressor of Ras 2 mRNA in spermLili GuoDeanna J. VolleRobert E. LewisThe kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2−/− mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility.http://www.sciencedirect.com/science/article/pii/S2211546314000400KSR2ScaffoldSperm |
| spellingShingle | Lili Guo Deanna J. Volle Robert E. Lewis Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm FEBS Open Bio KSR2 Scaffold Sperm |
| title | Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm |
| title_full | Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm |
| title_fullStr | Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm |
| title_full_unstemmed | Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm |
| title_short | Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm |
| title_sort | identification of a truncated kinase suppressor of ras 2 mrna in sperm |
| topic | KSR2 Scaffold Sperm |
| url | http://www.sciencedirect.com/science/article/pii/S2211546314000400 |
| work_keys_str_mv | AT liliguo identificationofatruncatedkinasesuppressorofras2mrnainsperm AT deannajvolle identificationofatruncatedkinasesuppressorofras2mrnainsperm AT robertelewis identificationofatruncatedkinasesuppressorofras2mrnainsperm |