Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties. Their good safety and tolerability profile, plus prom...

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Bibliographic Details
Main Authors:	Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Series:	iScience
Subjects:	Biological sciences Systems biology Cancer systems biology Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223004583

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