The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency

The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency

Studies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate. Our data on dehydroepiandrosterone (DHEA) and its hydroxylated metabolites clearly show that measurements of DHEA and its sulphate (DHE...

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Bibliographic Details
Main Authors: Michaela Dušková, Lucie Kolátorová Sosvorová, Martin Hill, Kateřina Šimůnková, Hana Jandíková, Hana Pospíšilová, Monika Šrámková, Mikuláš Kosák, Michal Kršek, Václav Hána, Luboslav Stárka
Format: Article
Language:English
Published: Karolinum Press 2016-01-01
Series:Prague Medical Report
Subjects:
Dehydroepiandrosterone
ACTH test
Insulin tolerance test
Adrenal insufficiency
7-hydroxy-DHEA
16-hydroxy-DHEA
Online Access:https://pmr.lf1.cuni.cz/117/2/0098/
Description
Summary:Studies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate. Our data on dehydroepiandrosterone (DHEA) and its hydroxylated metabolites clearly show that measurements of DHEA and its sulphate (DHEAS) are valuable markers of the integrity of the HPA (hypothalamus-pituitary-adrenal) axis. Assessments of HPA function should rely on measurements of baseline and/or stimulated serum cortisol concentrations, and C19 Δ5-steroids may provide additional information. The art of stimulation of 7- and 16-hydroxylated metabolites of DHEA can help our understanding of the formation sequence of these compounds.
ISSN:1214-6994
2336-2936

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