The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency
Studies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate. Our data on dehydroepiandrosterone (DHEA) and its hydroxylated metabolites clearly show that measurements of DHEA and its sulphate (DHE...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2016-01-01
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| Series: | Prague Medical Report |
| Subjects: | |
| Online Access: | https://pmr.lf1.cuni.cz/117/2/0098/ |
| _version_ | 1819089033786032128 |
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| author | Michaela Dušková Lucie Kolátorová Sosvorová Martin Hill Kateřina Šimůnková Hana Jandíková Hana Pospíšilová Monika Šrámková Mikuláš Kosák Michal Kršek Václav Hána Luboslav Stárka |
| author_facet | Michaela Dušková Lucie Kolátorová Sosvorová Martin Hill Kateřina Šimůnková Hana Jandíková Hana Pospíšilová Monika Šrámková Mikuláš Kosák Michal Kršek Václav Hána Luboslav Stárka |
| author_sort | Michaela Dušková |
| collection | DOAJ |
| description | Studies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate. Our data on dehydroepiandrosterone (DHEA) and its hydroxylated metabolites clearly show that measurements of DHEA and its sulphate (DHEAS) are valuable markers of the integrity of the HPA (hypothalamus-pituitary-adrenal) axis. Assessments of HPA function should rely on measurements of baseline and/or stimulated serum cortisol concentrations, and C19 Δ5-steroids may provide additional information. The art of stimulation of 7- and 16-hydroxylated metabolites of DHEA can help our understanding of the formation sequence of these compounds. |
| first_indexed | 2024-12-21T22:01:30Z |
| format | Article |
| id | doaj.art-682749d740a84ee18a60ac6e6c7d7195 |
| institution | Directory Open Access Journal |
| issn | 1214-6994 2336-2936 |
| language | English |
| last_indexed | 2024-12-21T22:01:30Z |
| publishDate | 2016-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Prague Medical Report |
| spelling | doaj.art-682749d740a84ee18a60ac6e6c7d71952022-12-21T18:48:48ZengKarolinum PressPrague Medical Report1214-69942336-29362016-01-0111729810710.14712/23362936.2016.10The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal InsufficiencyMichaela Dušková0Lucie Kolátorová Sosvorová1Martin Hill2Kateřina Šimůnková3Hana Jandíková4Hana Pospíšilová5Monika Šrámková6Mikuláš Kosák7Michal Kršek8Václav Hána9Luboslav Stárka10Institute of Endocrinology, Prague, Czech RepublicInstitute of Endocrinology, Prague, Czech RepublicInstitute of Endocrinology, Prague, Czech Republic3rd Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic; Institute of Endocrinology, Prague, Czech RepublicInstitute of Endocrinology, Prague, Czech RepublicInstitute of Endocrinology, Prague, Czech RepublicInstitute of Endocrinology, Prague, Czech Republic3rd Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic3rd Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic3rd Department of Medicine – Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech RepublicInstitute of Endocrinology, Prague, Czech RepublicStudies on the time course of ACTH- or insulin-induced hypoglycemia stimulating adrenal androgens are usually limited to dehydroepiandrosterone and/or its sulphate. Our data on dehydroepiandrosterone (DHEA) and its hydroxylated metabolites clearly show that measurements of DHEA and its sulphate (DHEAS) are valuable markers of the integrity of the HPA (hypothalamus-pituitary-adrenal) axis. Assessments of HPA function should rely on measurements of baseline and/or stimulated serum cortisol concentrations, and C19 Δ5-steroids may provide additional information. The art of stimulation of 7- and 16-hydroxylated metabolites of DHEA can help our understanding of the formation sequence of these compounds.https://pmr.lf1.cuni.cz/117/2/0098/DehydroepiandrosteroneACTH testInsulin tolerance testAdrenal insufficiency7-hydroxy-DHEA16-hydroxy-DHEA |
| spellingShingle | Michaela Dušková Lucie Kolátorová Sosvorová Martin Hill Kateřina Šimůnková Hana Jandíková Hana Pospíšilová Monika Šrámková Mikuláš Kosák Michal Kršek Václav Hána Luboslav Stárka The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency Prague Medical Report Dehydroepiandrosterone ACTH test Insulin tolerance test Adrenal insufficiency 7-hydroxy-DHEA 16-hydroxy-DHEA |
| title | The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency |
| title_full | The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency |
| title_fullStr | The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency |
| title_full_unstemmed | The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency |
| title_short | The Response of C19 Δ5-steroids to ACTH Stimulation and Hypoglycemia in Insulin Tolerance Test for Adrenal Insufficiency |
| title_sort | response of c19 δ5 steroids to acth stimulation and hypoglycemia in insulin tolerance test for adrenal insufficiency |
| topic | Dehydroepiandrosterone ACTH test Insulin tolerance test Adrenal insufficiency 7-hydroxy-DHEA 16-hydroxy-DHEA |
| url | https://pmr.lf1.cuni.cz/117/2/0098/ |
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