Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review
Chemical and natural toxic compounds can harm human health through a variety of mechanisms. Nowadays, herbal therapy is widely accepted as a safe method of treating toxicity. Garcinia mangostana (mangosteen) is a tree in the Clusiaceae family, and isoprenylated xanthones, its main constituents, are...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2023-05-01
|
| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | https://ijbms.mums.ac.ir/article_21803_48155e9eb18e709689635a875120d49a.pdf |
| _version_ | 1797848908072747008 |
|---|---|
| author | Aidin Mohammadi Zonouz Mahboobeh Ghasemzadeh Rahbardar Hossein Hosseinzadeh |
| author_facet | Aidin Mohammadi Zonouz Mahboobeh Ghasemzadeh Rahbardar Hossein Hosseinzadeh |
| author_sort | Aidin Mohammadi Zonouz |
| collection | DOAJ |
| description | Chemical and natural toxic compounds can harm human health through a variety of mechanisms. Nowadays, herbal therapy is widely accepted as a safe method of treating toxicity. Garcinia mangostana (mangosteen) is a tree in the Clusiaceae family, and isoprenylated xanthones, its main constituents, are a class of secondary metabolites having a variety of biological properties, such as anti-inflammatory, anti-oxidant, pro-apoptotic, anti-proliferative, antinociceptive, neuroprotective, hypoglycemic, and anti-obesity. In this review, the protective activities of mangosteen and its major components against natural and chemical toxicities in both in vivo and in vitro experiments were evaluated. The protective effects of mangosteen and its components are mediated primarily through oxidative stress inhibition, a decrease in the number of inflammatory cells such as lymphocytes, neutrophils, and eosinophils, reduction of inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), cyclooxygenase-2 (COX-2), prostaglandin (PG) E2, inducible nitric oxide synthase, and nuclear factor-ĸB (NF-ĸB), modulation of apoptosis and mitogen-activated protein kinase (MAPK) signaling pathways, reducing p65 entrance into the nucleus, α-smooth muscle actin (α-SMA), transforming growth factor β1 (TGFβ1), improving histological conditions, and inhibition in acetylcholinesterase activity. |
| first_indexed | 2024-04-09T18:36:19Z |
| format | Article |
| id | doaj.art-6827af2adbe647a4896fd88fdf43330b |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-09T18:36:19Z |
| publishDate | 2023-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-6827af2adbe647a4896fd88fdf43330b2023-04-11T10:06:54ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742023-05-0126549250310.22038/ijbms.2023.66900.1467421803Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A reviewAidin Mohammadi Zonouz0Mahboobeh Ghasemzadeh Rahbardar1Hossein Hosseinzadeh2School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranChemical and natural toxic compounds can harm human health through a variety of mechanisms. Nowadays, herbal therapy is widely accepted as a safe method of treating toxicity. Garcinia mangostana (mangosteen) is a tree in the Clusiaceae family, and isoprenylated xanthones, its main constituents, are a class of secondary metabolites having a variety of biological properties, such as anti-inflammatory, anti-oxidant, pro-apoptotic, anti-proliferative, antinociceptive, neuroprotective, hypoglycemic, and anti-obesity. In this review, the protective activities of mangosteen and its major components against natural and chemical toxicities in both in vivo and in vitro experiments were evaluated. The protective effects of mangosteen and its components are mediated primarily through oxidative stress inhibition, a decrease in the number of inflammatory cells such as lymphocytes, neutrophils, and eosinophils, reduction of inflammatory mediators such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), cyclooxygenase-2 (COX-2), prostaglandin (PG) E2, inducible nitric oxide synthase, and nuclear factor-ĸB (NF-ĸB), modulation of apoptosis and mitogen-activated protein kinase (MAPK) signaling pathways, reducing p65 entrance into the nucleus, α-smooth muscle actin (α-SMA), transforming growth factor β1 (TGFβ1), improving histological conditions, and inhibition in acetylcholinesterase activity.https://ijbms.mums.ac.ir/article_21803_48155e9eb18e709689635a875120d49a.pdfanalgesicsanti-inflammatory agents anti-oxidantsapoptosishypoglycemic agentsneuroprotective agentsphytotherapyxanthones |
| spellingShingle | Aidin Mohammadi Zonouz Mahboobeh Ghasemzadeh Rahbardar Hossein Hosseinzadeh Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review Iranian Journal of Basic Medical Sciences analgesics anti-inflammatory agents anti-oxidants apoptosis hypoglycemic agents neuroprotective agents phytotherapy xanthones |
| title | Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review |
| title_full | Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review |
| title_fullStr | Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review |
| title_full_unstemmed | Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review |
| title_short | Antidotal and protective effects of mangosteen (Garcinia mangostana) against natural and chemical toxicities: A review |
| title_sort | antidotal and protective effects of mangosteen garcinia mangostana against natural and chemical toxicities a review |
| topic | analgesics anti-inflammatory agents anti-oxidants apoptosis hypoglycemic agents neuroprotective agents phytotherapy xanthones |
| url | https://ijbms.mums.ac.ir/article_21803_48155e9eb18e709689635a875120d49a.pdf |
| work_keys_str_mv | AT aidinmohammadizonouz antidotalandprotectiveeffectsofmangosteengarciniamangostanaagainstnaturalandchemicaltoxicitiesareview AT mahboobehghasemzadehrahbardar antidotalandprotectiveeffectsofmangosteengarciniamangostanaagainstnaturalandchemicaltoxicitiesareview AT hosseinhosseinzadeh antidotalandprotectiveeffectsofmangosteengarciniamangostanaagainstnaturalandchemicaltoxicitiesareview |