Determinação de docetaxel e metabólitos em plasma por UPLC-MS/MS: desenvolvimento de metodologia analítica e aplicação clínica

Determinação de docetaxel e metabólitos em plasma por UPLC-MS/MS: desenvolvimento de metodologia analítica e aplicação clínica

A highly sensitive ultra-performance liquid chromatography tandem mass spectrometry method for the determination of Docetaxel and metabolites (M1+M3) in human plasma samples was developed and validated. The method employs a liquid-liquid extraction and a reversed phase separation Acquity® C18 column...

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Bibliographic Details
Main Authors:	Suziane Raymundo, Victória Vendramini Müller, Mariane Tegner, Andiara Artmann, Natália B. Andriguetti, Gilberto Schwartsmann, Rafael Linden, Marina V. Antunes
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Química
Series:	Química Nova
Subjects:	docetaxel metabolites validation therapeutic drug monitoring lc-ms/ms
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000400474&lng=en&tlng=en

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