Bayesian inference in epidemics: linear noise analysis

This paper offers a qualitative insight into the convergence of Bayesian parameter inference in a setup which mimics the modeling of the spread of a disease with associated disease measurements. Specifically, we are interested in the Bayesian model's convergence with increasing amounts of data...

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Main Authors: Samuel Bronstein, Stefan Engblom, Robin Marin
Format: Article
Language:English
Published: AIMS Press 2023-01-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2023193?viewType=HTML
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author Samuel Bronstein
Stefan Engblom
Robin Marin
author_facet Samuel Bronstein
Stefan Engblom
Robin Marin
author_sort Samuel Bronstein
collection DOAJ
description This paper offers a qualitative insight into the convergence of Bayesian parameter inference in a setup which mimics the modeling of the spread of a disease with associated disease measurements. Specifically, we are interested in the Bayesian model's convergence with increasing amounts of data under measurement limitations. Depending on how weakly informative the disease measurements are, we offer a kind of 'best case' as well as a 'worst case' analysis where, in the former case, we assume that the prevalence is directly accessible, while in the latter that only a binary signal corresponding to a prevalence detection threshold is available. Both cases are studied under an assumed so-called linear noise approximation as to the true dynamics. Numerical experiments test the sharpness of our results when confronted with more realistic situations for which analytical results are unavailable.
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spelling doaj.art-682c354db65b4354849ae1b5c57e90332023-01-31T02:36:57ZengAIMS PressMathematical Biosciences and Engineering1551-00182023-01-012024128415210.3934/mbe.2023193Bayesian inference in epidemics: linear noise analysisSamuel Bronstein 0Stefan Engblom 1Robin Marin21. Department of Mathematics and Applications, ENS Paris, 75005 Paris, France2. Division of Scientific Computing, Department of Information Technology, Uppsala University, SE-751 05 Uppsala, Sweden2. Division of Scientific Computing, Department of Information Technology, Uppsala University, SE-751 05 Uppsala, SwedenThis paper offers a qualitative insight into the convergence of Bayesian parameter inference in a setup which mimics the modeling of the spread of a disease with associated disease measurements. Specifically, we are interested in the Bayesian model's convergence with increasing amounts of data under measurement limitations. Depending on how weakly informative the disease measurements are, we offer a kind of 'best case' as well as a 'worst case' analysis where, in the former case, we assume that the prevalence is directly accessible, while in the latter that only a binary signal corresponding to a prevalence detection threshold is available. Both cases are studied under an assumed so-called linear noise approximation as to the true dynamics. Numerical experiments test the sharpness of our results when confronted with more realistic situations for which analytical results are unavailable.https://www.aimspress.com/article/doi/10.3934/mbe.2023193?viewType=HTMLparameter estimationbayesian modelingstochastic epidemiological modelsnetwork modelornstein-uhlenbeck process
spellingShingle Samuel Bronstein
Stefan Engblom
Robin Marin
Bayesian inference in epidemics: linear noise analysis
Mathematical Biosciences and Engineering
parameter estimation
bayesian modeling
stochastic epidemiological models
network model
ornstein-uhlenbeck process
title Bayesian inference in epidemics: linear noise analysis
title_full Bayesian inference in epidemics: linear noise analysis
title_fullStr Bayesian inference in epidemics: linear noise analysis
title_full_unstemmed Bayesian inference in epidemics: linear noise analysis
title_short Bayesian inference in epidemics: linear noise analysis
title_sort bayesian inference in epidemics linear noise analysis
topic parameter estimation
bayesian modeling
stochastic epidemiological models
network model
ornstein-uhlenbeck process
url https://www.aimspress.com/article/doi/10.3934/mbe.2023193?viewType=HTML
work_keys_str_mv AT samuelbronstein bayesianinferenceinepidemicslinearnoiseanalysis
AT stefanengblom bayesianinferenceinepidemicslinearnoiseanalysis
AT robinmarin bayesianinferenceinepidemicslinearnoiseanalysis