NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study
<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease is prevalent and frequently unrecognized in patients with chronic obstructive pulmonary disease (COPD). NT-proBNP is an established risk factor in patients with heart failure. NT-proBNP may also be released fro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-10-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | http://respiratory-research.com/content/13/1/97 |
| _version_ | 1818682876872359936 |
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| author | Høiseth Arne Omland Torbjørn Hagve Tor-Arne Brekke Pål H Søyseth Vidar |
| author_facet | Høiseth Arne Omland Torbjørn Hagve Tor-Arne Brekke Pål H Søyseth Vidar |
| author_sort | Høiseth Arne |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Cardiovascular disease is prevalent and frequently unrecognized in patients with chronic obstructive pulmonary disease (COPD). NT-proBNP is an established risk factor in patients with heart failure. NT-proBNP may also be released from the right ventricle. Thus serum NT-proBNP may be elevated during acute exacerbations of COPD (AECOPD). The prognostic value of NT-proBNP in patients hospitalized with AECOPD is sparsely studied. Our objective was to test the hypothesis that NT-proBNP independently predicts long term mortality following AECOPD.</p> <p>Methods</p> <p>A prospective cohort study of 99 patients with 217 admissions with AECOPD. Clinical, electrocardiographic, radiological and biochemical data were collected at index and repeat admissions and analyzed in an extended survival analysis with time-dependent covariables.</p> <p>Results</p> <p>Median follow-up time was 1.9 years, and 57 patients died during follow-up. NT-proBNP tertile limits were 264.4 and 909 pg/mL, and NT-proBNP in tertiles 1 through 3 was associated with mortality rates of 8.6, 35 and 62 per 100 patient-years, respectively (age-adjusted log-rank p<0.0001). After adjustment for age, gender, peripheral edema, cephalization and cTnT in a multivariable survival model, the corresponding hazard ratios for dying were 2.4 (0.95-6.0) and 3.2 (1.3-8.1) (with 95% confidence intervals in parentheses, p-value for trend 0.013).</p> <p>Conclusions</p> <p>NT-proBNP is a strong and independent determinant of mortality after AECOPD.</p> |
| first_indexed | 2024-12-17T10:25:49Z |
| format | Article |
| id | doaj.art-682c7d860586491abb1e11d669ce75bb |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-17T10:25:49Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-682c7d860586491abb1e11d669ce75bb2022-12-21T21:52:40ZengBMCRespiratory Research1465-99212012-10-011319710.1186/1465-9921-13-97NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort studyHøiseth ArneOmland TorbjørnHagve Tor-ArneBrekke Pål HSøyseth Vidar<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease is prevalent and frequently unrecognized in patients with chronic obstructive pulmonary disease (COPD). NT-proBNP is an established risk factor in patients with heart failure. NT-proBNP may also be released from the right ventricle. Thus serum NT-proBNP may be elevated during acute exacerbations of COPD (AECOPD). The prognostic value of NT-proBNP in patients hospitalized with AECOPD is sparsely studied. Our objective was to test the hypothesis that NT-proBNP independently predicts long term mortality following AECOPD.</p> <p>Methods</p> <p>A prospective cohort study of 99 patients with 217 admissions with AECOPD. Clinical, electrocardiographic, radiological and biochemical data were collected at index and repeat admissions and analyzed in an extended survival analysis with time-dependent covariables.</p> <p>Results</p> <p>Median follow-up time was 1.9 years, and 57 patients died during follow-up. NT-proBNP tertile limits were 264.4 and 909 pg/mL, and NT-proBNP in tertiles 1 through 3 was associated with mortality rates of 8.6, 35 and 62 per 100 patient-years, respectively (age-adjusted log-rank p<0.0001). After adjustment for age, gender, peripheral edema, cephalization and cTnT in a multivariable survival model, the corresponding hazard ratios for dying were 2.4 (0.95-6.0) and 3.2 (1.3-8.1) (with 95% confidence intervals in parentheses, p-value for trend 0.013).</p> <p>Conclusions</p> <p>NT-proBNP is a strong and independent determinant of mortality after AECOPD.</p>http://respiratory-research.com/content/13/1/97Chronic obstructive pulmonary diseaseHeart failureNT-proBNPMortality |
| spellingShingle | Høiseth Arne Omland Torbjørn Hagve Tor-Arne Brekke Pål H Søyseth Vidar NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study Respiratory Research Chronic obstructive pulmonary disease Heart failure NT-proBNP Mortality |
| title | NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study |
| title_full | NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study |
| title_fullStr | NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study |
| title_full_unstemmed | NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study |
| title_short | NT-proBNP independently predicts long term mortality after acute exacerbation of COPD – a prospective cohort study |
| title_sort | nt probnp independently predicts long term mortality after acute exacerbation of copd a prospective cohort study |
| topic | Chronic obstructive pulmonary disease Heart failure NT-proBNP Mortality |
| url | http://respiratory-research.com/content/13/1/97 |
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