Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review
Abstract Dysregulation of the innate immune system and inflammatory-related pathways has been implicated in hematopoietic defects in the bone marrow microenvironment and associated with aging, clonal hematopoiesis, myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). As the innate immu...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-023-00422-1 |
| _version_ | 1797784763138834432 |
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| author | Charan Thej Reddy Vegivinti Praneeth Reddy Keesari Sindhusha Veeraballi Catarina Maria Pina Martins Maia Ansh Krishnachandra Mehta Rohit Reddy Lavu Rahul Kumar Thakur Sri Harsha Tella Riya Patel Venkata Kiranmayi Kakumani Yashwitha Sai Pulakurthi Srinivas Aluri Ritesh Kumar Aggarwal Nandini Ramachandra Rongbao Zhao Srabani Sahu Aditi Shastri Amit Verma |
| author_facet | Charan Thej Reddy Vegivinti Praneeth Reddy Keesari Sindhusha Veeraballi Catarina Maria Pina Martins Maia Ansh Krishnachandra Mehta Rohit Reddy Lavu Rahul Kumar Thakur Sri Harsha Tella Riya Patel Venkata Kiranmayi Kakumani Yashwitha Sai Pulakurthi Srinivas Aluri Ritesh Kumar Aggarwal Nandini Ramachandra Rongbao Zhao Srabani Sahu Aditi Shastri Amit Verma |
| author_sort | Charan Thej Reddy Vegivinti |
| collection | DOAJ |
| description | Abstract Dysregulation of the innate immune system and inflammatory-related pathways has been implicated in hematopoietic defects in the bone marrow microenvironment and associated with aging, clonal hematopoiesis, myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). As the innate immune system and its pathway regulators have been implicated in the pathogenesis of MDS/AML, novel approaches targeting these pathways have shown promising results. Variability in expression of Toll like receptors (TLRs), abnormal levels of MyD88 and subsequent activation of NF-κβ, dysregulated IL1-receptor associated kinases (IRAK), alterations in TGF-β and SMAD signaling, high levels of S100A8/A9 have all been implicated in pathogenesis of MDS/AML. In this review we not only discuss the interplay of various innate immune pathways in MDS pathogenesis but also focus on potential therapeutic targets from recent clinical trials including the use of monoclonal antibodies and small molecule inhibitors against these pathways. |
| first_indexed | 2024-03-13T00:44:31Z |
| format | Article |
| id | doaj.art-683079f0ef6041bf9cc850cc07833d73 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-03-13T00:44:31Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-683079f0ef6041bf9cc850cc07833d732023-07-09T11:08:20ZengBMCExperimental Hematology & Oncology2162-36192023-07-0112111210.1186/s40164-023-00422-1Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative reviewCharan Thej Reddy Vegivinti0Praneeth Reddy Keesari1Sindhusha Veeraballi2Catarina Maria Pina Martins Maia3Ansh Krishnachandra Mehta4Rohit Reddy Lavu5Rahul Kumar Thakur6Sri Harsha Tella7Riya Patel8Venkata Kiranmayi Kakumani9Yashwitha Sai Pulakurthi10Srinivas Aluri11Ritesh Kumar Aggarwal12Nandini Ramachandra13Rongbao Zhao14Srabani Sahu15Aditi Shastri16Amit Verma17Department of Medicine, Jacobi Medical Center/Albert Einstein College of MedicineDepartment of Medicine, Staten Island University HospitalDepartment of Medicine, Saint Michael’s Medical CenterDepartment of Hematology and Oncology, National Institute of Health Department of Oncology, Albert Einstein College of MedicineDepartment of Oncology, Yashoda hospitalsDepartment of Medicine, Jacobi Medical Center/Albert Einstein College of MedicineDepartment of Medical Oncology, Mayo ClinicDepartment of Hematology and Oncology, University of Buffalo - Roswell Park Comprehensive Cancer CenterHarvard Medical Faculty Physicians, Beth Israel Deaconess Medical CenterDepartment of Medicine, Saint Michael’s Medical Center Department of Oncology, Albert Einstein College of Medicine Department of Oncology, Albert Einstein College of Medicine Department of Oncology, Albert Einstein College of Medicine Department of Oncology, Albert Einstein College of Medicine Department of Oncology, Albert Einstein College of Medicine Department of Oncology, Albert Einstein College of Medicine Department of Oncology, Albert Einstein College of MedicineAbstract Dysregulation of the innate immune system and inflammatory-related pathways has been implicated in hematopoietic defects in the bone marrow microenvironment and associated with aging, clonal hematopoiesis, myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML). As the innate immune system and its pathway regulators have been implicated in the pathogenesis of MDS/AML, novel approaches targeting these pathways have shown promising results. Variability in expression of Toll like receptors (TLRs), abnormal levels of MyD88 and subsequent activation of NF-κβ, dysregulated IL1-receptor associated kinases (IRAK), alterations in TGF-β and SMAD signaling, high levels of S100A8/A9 have all been implicated in pathogenesis of MDS/AML. In this review we not only discuss the interplay of various innate immune pathways in MDS pathogenesis but also focus on potential therapeutic targets from recent clinical trials including the use of monoclonal antibodies and small molecule inhibitors against these pathways.https://doi.org/10.1186/s40164-023-00422-1Myelodysplastic syndromes (MDS)Acute myeloid leukemia (AML)Innate Immune pathwaysTumor microenvironment (TME)Toll like receptors (TLRs)IL1 receptor Associated kinase (IRAK) |
| spellingShingle | Charan Thej Reddy Vegivinti Praneeth Reddy Keesari Sindhusha Veeraballi Catarina Maria Pina Martins Maia Ansh Krishnachandra Mehta Rohit Reddy Lavu Rahul Kumar Thakur Sri Harsha Tella Riya Patel Venkata Kiranmayi Kakumani Yashwitha Sai Pulakurthi Srinivas Aluri Ritesh Kumar Aggarwal Nandini Ramachandra Rongbao Zhao Srabani Sahu Aditi Shastri Amit Verma Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review Experimental Hematology & Oncology Myelodysplastic syndromes (MDS) Acute myeloid leukemia (AML) Innate Immune pathways Tumor microenvironment (TME) Toll like receptors (TLRs) IL1 receptor Associated kinase (IRAK) |
| title | Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review |
| title_full | Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review |
| title_fullStr | Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review |
| title_full_unstemmed | Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review |
| title_short | Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review |
| title_sort | role of innate immunological inflammatory pathways in myelodysplastic syndromes and aml a narrative review |
| topic | Myelodysplastic syndromes (MDS) Acute myeloid leukemia (AML) Innate Immune pathways Tumor microenvironment (TME) Toll like receptors (TLRs) IL1 receptor Associated kinase (IRAK) |
| url | https://doi.org/10.1186/s40164-023-00422-1 |
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