Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, Colombia
Introduction: Major amputation is a significant intervention in advanced stages of peripheral arterial disease (PAD) and has important morbidity and mortality rates. Despite being a frequently performed procedure in Colombia, local statistics on its frequency and outcomes are not available. Objecti...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Antioquia
2023-10-01
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| Series: | Iatreia |
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| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/348853 |
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| author | Cristhian Fabian Acero-Murillo Nicolas Dayam Rosales-Parra José Andrés Uribe-Munera Miguel Ángel Rosales-Parra René Fernando Timarán-Rodríguez |
| author_facet | Cristhian Fabian Acero-Murillo Nicolas Dayam Rosales-Parra José Andrés Uribe-Munera Miguel Ángel Rosales-Parra René Fernando Timarán-Rodríguez |
| author_sort | Cristhian Fabian Acero-Murillo |
| collection | DOAJ |
| description | Introduction: Major amputation is a significant intervention in advanced stages of peripheral arterial disease (PAD) and has important morbidity and mortality rates. Despite being a frequently performed procedure in Colombia, local statistics on its frequency and outcomes are not available.
Objectives: To analyze the morbidity and mortality in patients with lower limb PAD during the 30 days following major amputation or during the index hospitalization. To identify factors related to the outcome and characterize the population.
Methods: A retrospective study of patients with lower limb PAD who underwent major amputation for acute ischemia (AI) or chronic limb-threatening ischemia (CLTI) between March 2011 and December 2019 at Hospital Universitario San Vicente Fundación in Medellín, Colombia (HUSVF). Variables related to the underlying disease and perioperative morbidity were calculated in a general analysis and by groups, according to the level of amputation.
Results: A total of 558 major amputations were performed, 83.5% for CLTI. The overall mortality rate was 14.7%, with 32.6% in AI and 11.2% in CLTI. The most frequent complication was delirium (28.8%). After multivariate analysis, no influential factors were identified for fatal outcomes, except for cardiovascular complications in AI.
Conclusions: In this study, the only variable related to early mortality was cardiovascular complications in patients with AI. The percentages of heart disease are lower compared to those reported in studies from other countries. The most common complication was delirium. |
| first_indexed | 2024-03-11T19:57:25Z |
| format | Article |
| id | doaj.art-6831c11af9cc4c4180d144a2cd71e02a |
| institution | Directory Open Access Journal |
| issn | 0121-0793 2011-7965 |
| language | Spanish |
| last_indexed | 2024-03-11T19:57:25Z |
| publishDate | 2023-10-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Iatreia |
| spelling | doaj.art-6831c11af9cc4c4180d144a2cd71e02a2023-10-04T19:21:37ZspaUniversidad de AntioquiaIatreia0121-07932011-79652023-10-0136447148010.17533/udea.iatreia.199Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, ColombiaCristhian Fabian Acero-Murillo0https://orcid.org/0000-0001-8828-9301Nicolas Dayam Rosales-Parra1https://orcid.org/0000-0003-2084-1715José Andrés Uribe-Munera2https://orcid.org/0000-0003-1648-3660Miguel Ángel Rosales-Parra3https://orcid.org/0000-0002-7781-5107René Fernando Timarán-Rodríguez4https://orcid.org/0000-0002-2604-4699E.S.E Hospital San Jose de Guaduas, Guaduas, CundinamarcaUniversidad de Antioquia, Medellín, ColombiaUniversidad de Antioquia, Medellín, ColombiaUniversidad de Antioquia, Medellín, ColombiaHospital Universitario San Vicente Fundación, Medellín, ColombiaIntroduction: Major amputation is a significant intervention in advanced stages of peripheral arterial disease (PAD) and has important morbidity and mortality rates. Despite being a frequently performed procedure in Colombia, local statistics on its frequency and outcomes are not available. Objectives: To analyze the morbidity and mortality in patients with lower limb PAD during the 30 days following major amputation or during the index hospitalization. To identify factors related to the outcome and characterize the population. Methods: A retrospective study of patients with lower limb PAD who underwent major amputation for acute ischemia (AI) or chronic limb-threatening ischemia (CLTI) between March 2011 and December 2019 at Hospital Universitario San Vicente Fundación in Medellín, Colombia (HUSVF). Variables related to the underlying disease and perioperative morbidity were calculated in a general analysis and by groups, according to the level of amputation. Results: A total of 558 major amputations were performed, 83.5% for CLTI. The overall mortality rate was 14.7%, with 32.6% in AI and 11.2% in CLTI. The most frequent complication was delirium (28.8%). After multivariate analysis, no influential factors were identified for fatal outcomes, except for cardiovascular complications in AI. Conclusions: In this study, the only variable related to early mortality was cardiovascular complications in patients with AI. The percentages of heart disease are lower compared to those reported in studies from other countries. The most common complication was delirium.https://revistas.udea.edu.co/index.php/iatreia/article/view/348853peripheral arterial diseasemortalitymorbiditycolombia |
| spellingShingle | Cristhian Fabian Acero-Murillo Nicolas Dayam Rosales-Parra José Andrés Uribe-Munera Miguel Ángel Rosales-Parra René Fernando Timarán-Rodríguez Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, Colombia Iatreia peripheral arterial disease mortality morbidity colombia |
| title | Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, Colombia |
| title_full | Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, Colombia |
| title_fullStr | Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, Colombia |
| title_full_unstemmed | Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, Colombia |
| title_short | Early Outcomes in Major Amputations of Patients with Peripheral Arterial Disease of Lower Limbs: A Study in a Referral Hospital in Medellín, Colombia |
| title_sort | early outcomes in major amputations of patients with peripheral arterial disease of lower limbs a study in a referral hospital in medellin colombia |
| topic | peripheral arterial disease mortality morbidity colombia |
| url | https://revistas.udea.edu.co/index.php/iatreia/article/view/348853 |
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