Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia
Schizophrenia is a complex neuropsychiatric disorder affected by both genetic and epigenetic factors. Except for neuronal dysfunction, oligodendroglial abnormalities also contribute to the disease pathogenesis, characterized by a robust dysregulation of oligodendrocyte and myelin related genes. Accu...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2022.823708/full |
| _version_ | 1818694981885362176 |
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| author | Mei Li Mei Li Lan Xiao Xianjun Chen Xianjun Chen |
| author_facet | Mei Li Mei Li Lan Xiao Xianjun Chen Xianjun Chen |
| author_sort | Mei Li |
| collection | DOAJ |
| description | Schizophrenia is a complex neuropsychiatric disorder affected by both genetic and epigenetic factors. Except for neuronal dysfunction, oligodendroglial abnormalities also contribute to the disease pathogenesis, characterized by a robust dysregulation of oligodendrocyte and myelin related genes. Accumulating evidence shows that histone modifications play important roles in transcriptional regulation of the genes crucial for oligodendrocyte differentiation and myelination. Specifically, the histone acetylation and methylation were two well-recognized histone modification abnormalities in the schizophrenic brains. In this mini-review, we will describe the dynamic changes of histone acetylation and methylation in schizophrenia, which may coordinate and induce deleterious epigenetic memory in oligodendroglial cells, and further lead to oligodendrocyte and myelin deficits. Precise modulation of histone modification status in oligodendroglial cells needs to secure the balance of epigenetic marks, which may revise the therapeutic strategy for the white matter etiology of neuropsychiatric disorders. |
| first_indexed | 2024-12-17T13:38:13Z |
| format | Article |
| id | doaj.art-6837b7ea07f64758aed4f563e5b5d8ce |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-17T13:38:13Z |
| publishDate | 2022-03-01 |
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| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-6837b7ea07f64758aed4f563e5b5d8ce2022-12-21T21:46:22ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022022-03-011610.3389/fncel.2022.823708823708Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in SchizophreniaMei Li0Mei Li1Lan Xiao2Xianjun Chen3Xianjun Chen4Department of Physiology, Research Center of Neuroscience, College of Basic Medical Science, Chongqing Medical University, Chongqing, ChinaLaboratory of Human Physiology, Lab Teaching and Management Center, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Institute of Brain and Intelligence, Army Medical University (Third Military Medical University), Chongqing, ChinaDepartment of Physiology, Research Center of Neuroscience, College of Basic Medical Science, Chongqing Medical University, Chongqing, ChinaDepartment of Histology and Embryology, Institute of Brain and Intelligence, Army Medical University (Third Military Medical University), Chongqing, ChinaSchizophrenia is a complex neuropsychiatric disorder affected by both genetic and epigenetic factors. Except for neuronal dysfunction, oligodendroglial abnormalities also contribute to the disease pathogenesis, characterized by a robust dysregulation of oligodendrocyte and myelin related genes. Accumulating evidence shows that histone modifications play important roles in transcriptional regulation of the genes crucial for oligodendrocyte differentiation and myelination. Specifically, the histone acetylation and methylation were two well-recognized histone modification abnormalities in the schizophrenic brains. In this mini-review, we will describe the dynamic changes of histone acetylation and methylation in schizophrenia, which may coordinate and induce deleterious epigenetic memory in oligodendroglial cells, and further lead to oligodendrocyte and myelin deficits. Precise modulation of histone modification status in oligodendroglial cells needs to secure the balance of epigenetic marks, which may revise the therapeutic strategy for the white matter etiology of neuropsychiatric disorders.https://www.frontiersin.org/articles/10.3389/fncel.2022.823708/fulloligodendrocytemyelinhistone acetylationhistone methylationepigeneticschizophrenia |
| spellingShingle | Mei Li Mei Li Lan Xiao Xianjun Chen Xianjun Chen Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia Frontiers in Cellular Neuroscience oligodendrocyte myelin histone acetylation histone methylation epigenetic schizophrenia |
| title | Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia |
| title_full | Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia |
| title_fullStr | Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia |
| title_full_unstemmed | Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia |
| title_short | Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia |
| title_sort | histone acetylation and methylation underlie oligodendroglial and myelin susceptibility in schizophrenia |
| topic | oligodendrocyte myelin histone acetylation histone methylation epigenetic schizophrenia |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2022.823708/full |
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