Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized study
Background: Atrophic acne scarring is an unpleasant and often permanent complication and a therapeutic challenge for dermatologists. Platelet-poor plasma (PPP) gel injections are derived from the patient’s own blood and used as a “biofiller” for skin rejuvenation. Objectives: The objective was to st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Journal of Cutaneous and Aesthetic Surgery |
| Subjects: | |
| Online Access: | http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=3;spage=260;epage=266;aulast=Bhatt |
| _version_ | 1811313475221192704 |
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| author | Mansi Bhatt Varsha Jamale Mohan Kale Asma A Hussain Balkrishna P Nikam |
| author_facet | Mansi Bhatt Varsha Jamale Mohan Kale Asma A Hussain Balkrishna P Nikam |
| author_sort | Mansi Bhatt |
| collection | DOAJ |
| description | Background: Atrophic acne scarring is an unpleasant and often permanent complication and a therapeutic challenge for dermatologists. Platelet-poor plasma (PPP) gel injections are derived from the patient’s own blood and used as a “biofiller” for skin rejuvenation. Objectives: The objective was to study the efficacy and safety profile of PPP gel in atrophic acne scars. Materials and Methods: Thirty patients with atrophic acne scars were included in the study. Topical anesthesia was applied on the area of interest 45 min prior to the procedure. 20 mL of blood was collected in eight sodium citrate bulbs and centrifuged to get PPP that is coagulated with heat to form gel. This gel (biofiller) was injected in the scarred areas monthly for 6 months. Patients were evaluated using Goodman and Baron Scar (GBS) scale (quantitative and qualitative), Physician Global Assessment, and Visual Analogue Scale (VAS) at each visit. The final visit was after 3 months of the last procedure. Results: The mean value of GBS at the first visit was 28, which reduced to 8.2 at the final visit. The analysis of variance test was applied to the quantitative scale from the baseline visit to the final visit. The F value was 462.55 with a P value < 0.0001. The paired t-test was applied for the GBS quantitative scale, which showed a value of 22.86 with a P value of <0.001. Transient local side effects were noted. Conclusion: Biofiller is efficacious in improving atrophic acne scars. It is a simple, minimally invasive, cost-effective procedure with no risk of immunogenic reaction. |
| first_indexed | 2024-04-13T10:54:28Z |
| format | Article |
| id | doaj.art-683a59b2edfe458fb0024c2b5e0d2f6a |
| institution | Directory Open Access Journal |
| issn | 0974-2077 |
| language | English |
| last_indexed | 2024-04-13T10:54:28Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cutaneous and Aesthetic Surgery |
| spelling | doaj.art-683a59b2edfe458fb0024c2b5e0d2f6a2022-12-22T02:49:33ZengWolters Kluwer Medknow PublicationsJournal of Cutaneous and Aesthetic Surgery0974-20772022-01-0115326026610.4103/JCAS.JCAS_58_22Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized studyMansi BhattVarsha JamaleMohan KaleAsma A HussainBalkrishna P NikamBackground: Atrophic acne scarring is an unpleasant and often permanent complication and a therapeutic challenge for dermatologists. Platelet-poor plasma (PPP) gel injections are derived from the patient’s own blood and used as a “biofiller” for skin rejuvenation. Objectives: The objective was to study the efficacy and safety profile of PPP gel in atrophic acne scars. Materials and Methods: Thirty patients with atrophic acne scars were included in the study. Topical anesthesia was applied on the area of interest 45 min prior to the procedure. 20 mL of blood was collected in eight sodium citrate bulbs and centrifuged to get PPP that is coagulated with heat to form gel. This gel (biofiller) was injected in the scarred areas monthly for 6 months. Patients were evaluated using Goodman and Baron Scar (GBS) scale (quantitative and qualitative), Physician Global Assessment, and Visual Analogue Scale (VAS) at each visit. The final visit was after 3 months of the last procedure. Results: The mean value of GBS at the first visit was 28, which reduced to 8.2 at the final visit. The analysis of variance test was applied to the quantitative scale from the baseline visit to the final visit. The F value was 462.55 with a P value < 0.0001. The paired t-test was applied for the GBS quantitative scale, which showed a value of 22.86 with a P value of <0.001. Transient local side effects were noted. Conclusion: Biofiller is efficacious in improving atrophic acne scars. It is a simple, minimally invasive, cost-effective procedure with no risk of immunogenic reaction.http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=3;spage=260;epage=266;aulast=Bhattatrophic acne scarsautologous fillerbiofillerdermal fillerplatelet-poor plasma |
| spellingShingle | Mansi Bhatt Varsha Jamale Mohan Kale Asma A Hussain Balkrishna P Nikam Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized study Journal of Cutaneous and Aesthetic Surgery atrophic acne scars autologous filler biofiller dermal filler platelet-poor plasma |
| title | Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized study |
| title_full | Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized study |
| title_fullStr | Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized study |
| title_full_unstemmed | Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized study |
| title_short | Monotherapy of biofiller for atrophic acne scars: A prospective nonrandomized study |
| title_sort | monotherapy of biofiller for atrophic acne scars a prospective nonrandomized study |
| topic | atrophic acne scars autologous filler biofiller dermal filler platelet-poor plasma |
| url | http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=3;spage=260;epage=266;aulast=Bhatt |
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