<span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior
More and more evidence shows how brain energy metabolism is the linkage between physiological and morphological synaptic plasticity and memory consolidation. Different types of memory are associated with differential inputs, each with specific inputs that are upstream diverse molecular cascades depe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/11/8/548 |
| _version_ | 1797522919821148160 |
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| author | María Fernanda Veloz Castillo Pierre J. Magistretti Corrado Calì |
| author_facet | María Fernanda Veloz Castillo Pierre J. Magistretti Corrado Calì |
| author_sort | María Fernanda Veloz Castillo |
| collection | DOAJ |
| description | More and more evidence shows how brain energy metabolism is the linkage between physiological and morphological synaptic plasticity and memory consolidation. Different types of memory are associated with differential inputs, each with specific inputs that are upstream diverse molecular cascades depending on the receptor activity. No matter how heterogeneous the response is, energy availability represents the lowest common denominator since all these mechanisms are energy consuming and the brain networks adapt their performance accordingly. Astrocytes exert a primary role in this sense by acting as an energy buffer; glycogen granules, a mechanism to store glucose, are redistributed at glance and conveyed to neurons via the Astrocyte–Neuron Lactate Shuttle (ANLS). Here, we review how different types of memory relate to the mechanisms of energy delivery in the brain. |
| first_indexed | 2024-03-10T08:36:10Z |
| format | Article |
| id | doaj.art-683c4c79e7774439a3fab3ee2d41d068 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T08:36:10Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-683c4c79e7774439a3fab3ee2d41d0682023-11-22T08:39:56ZengMDPI AGMetabolites2218-19892021-08-0111854810.3390/metabo11080548<span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and BehaviorMaría Fernanda Veloz Castillo0Pierre J. Magistretti1Corrado Calì2Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi ArabiaBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi ArabiaDipartimento di Neuroscienze “Rita Levi Montalcini”, Università degli Studi di Torino, 10124 Torino, ItalyMore and more evidence shows how brain energy metabolism is the linkage between physiological and morphological synaptic plasticity and memory consolidation. Different types of memory are associated with differential inputs, each with specific inputs that are upstream diverse molecular cascades depending on the receptor activity. No matter how heterogeneous the response is, energy availability represents the lowest common denominator since all these mechanisms are energy consuming and the brain networks adapt their performance accordingly. Astrocytes exert a primary role in this sense by acting as an energy buffer; glycogen granules, a mechanism to store glucose, are redistributed at glance and conveyed to neurons via the Astrocyte–Neuron Lactate Shuttle (ANLS). Here, we review how different types of memory relate to the mechanisms of energy delivery in the brain.https://www.mdpi.com/2218-1989/11/8/548lactateglycogenmetabolismbehaviorlearning |
| spellingShingle | María Fernanda Veloz Castillo Pierre J. Magistretti Corrado Calì <span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior Metabolites lactate glycogen metabolism behavior learning |
| title | <span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior |
| title_full | <span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior |
| title_fullStr | <span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior |
| title_full_unstemmed | <span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior |
| title_short | <span style="font-variant: small-caps">l</span>-Lactate: Food for Thoughts, Memory and Behavior |
| title_sort | span style font variant small caps l span lactate food for thoughts memory and behavior |
| topic | lactate glycogen metabolism behavior learning |
| url | https://www.mdpi.com/2218-1989/11/8/548 |
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