Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration.
Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4269422?pdf=render |
| _version_ | 1819264009178710016 |
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| author | João W Silveira Ana Carolina Issy Vitor A Castania Carlos E G Salmon Marcello H Nogueira-Barbosa Francisco S Guimarães Helton L A Defino Elaine Del Bel |
| author_facet | João W Silveira Ana Carolina Issy Vitor A Castania Carlos E G Salmon Marcello H Nogueira-Barbosa Francisco S Guimarães Helton L A Defino Elaine Del Bel |
| author_sort | João W Silveira |
| collection | DOAJ |
| description | Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties. However, possible therapeutic effects of cannabidiol on intervertebral disc degeneration have not been investigated yet. The present study investigated the effects of cannabidiol intradiscal injection in the coccygeal intervertebral disc degeneration induced by the needle puncture model using magnetic resonance imaging (MRI) and histological analyses. Disc injury was induced in the tail of male Wistar rats via a single needle puncture. The discs selected for injury were punctured percutaneously using a 21-gauge needle. MRI and histological evaluation were employed to assess the results. The effects of intradiscal injection of cannabidiol (30, 60 or 120 nmol) injected immediately after lesion were analyzed acutely (2 days) by MRI. The experimental group that received cannabidiol 120 nmol was resubmitted to MRI examination and then to histological analyses 15 days after lesion/cannabidiol injection. The needle puncture produced a significant disc injury detected both by MRI and histological analyses. Cannabidiol significantly attenuated the effects of disc injury induced by the needle puncture. Considering that cannabidiol presents an extremely safe profile and is currently being used clinically, these results suggest that this compound could be useful in the treatment of intervertebral disc degeneration. |
| first_indexed | 2024-12-23T20:22:40Z |
| format | Article |
| id | doaj.art-683eac660da149e68c6a71fdec73432b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T20:22:40Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-683eac660da149e68c6a71fdec73432b2022-12-21T17:32:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01912e11316110.1371/journal.pone.0113161Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration.João W SilveiraAna Carolina IssyVitor A CastaniaCarlos E G SalmonMarcello H Nogueira-BarbosaFrancisco S GuimarãesHelton L A DefinoElaine Del BelDisc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties. However, possible therapeutic effects of cannabidiol on intervertebral disc degeneration have not been investigated yet. The present study investigated the effects of cannabidiol intradiscal injection in the coccygeal intervertebral disc degeneration induced by the needle puncture model using magnetic resonance imaging (MRI) and histological analyses. Disc injury was induced in the tail of male Wistar rats via a single needle puncture. The discs selected for injury were punctured percutaneously using a 21-gauge needle. MRI and histological evaluation were employed to assess the results. The effects of intradiscal injection of cannabidiol (30, 60 or 120 nmol) injected immediately after lesion were analyzed acutely (2 days) by MRI. The experimental group that received cannabidiol 120 nmol was resubmitted to MRI examination and then to histological analyses 15 days after lesion/cannabidiol injection. The needle puncture produced a significant disc injury detected both by MRI and histological analyses. Cannabidiol significantly attenuated the effects of disc injury induced by the needle puncture. Considering that cannabidiol presents an extremely safe profile and is currently being used clinically, these results suggest that this compound could be useful in the treatment of intervertebral disc degeneration.http://europepmc.org/articles/PMC4269422?pdf=render |
| spellingShingle | João W Silveira Ana Carolina Issy Vitor A Castania Carlos E G Salmon Marcello H Nogueira-Barbosa Francisco S Guimarães Helton L A Defino Elaine Del Bel Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. PLoS ONE |
| title | Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. |
| title_full | Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. |
| title_fullStr | Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. |
| title_full_unstemmed | Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. |
| title_short | Protective effects of cannabidiol on lesion-induced intervertebral disc degeneration. |
| title_sort | protective effects of cannabidiol on lesion induced intervertebral disc degeneration |
| url | http://europepmc.org/articles/PMC4269422?pdf=render |
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