The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
Breast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10737 |
| _version_ | 1797591552770441216 |
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| author | Víctor Marín Viviana Burgos Rebeca Pérez Durvanei Augusto Maria Paulo Pardi Cristian Paz |
| author_facet | Víctor Marín Viviana Burgos Rebeca Pérez Durvanei Augusto Maria Paulo Pardi Cristian Paz |
| author_sort | Víctor Marín |
| collection | DOAJ |
| description | Breast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface receptors, which makes treatment difficult. Epigallocatechin-3-gallate (EGCG) is a natural polyphenol isolated as the main component in green tea; it has shown multiple beneficial effects in breast cancer, controlling proliferation, invasion, apoptosis, inflammation, and demethylation of DNA. These properties were proved in vitro and in vivo together with synergistic effects in combination with traditional chemotherapy, increasing the effectiveness of the treatment. This review focuses on the effects of EGCG on the functional capabilities acquired by breast tumor cells during its multistep development, the molecular and signal pathways involved, the synergistic effects in combination with current drugs, and how nanomaterials can improve its bioavailability on breast cancer treatment. |
| first_indexed | 2024-03-11T01:39:05Z |
| format | Article |
| id | doaj.art-683f53be1f2b44ba91930296fb2b2b34 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:39:05Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-683f53be1f2b44ba91930296fb2b2b342023-11-18T16:42:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131073710.3390/ijms241310737The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer TreatmentVíctor Marín0Viviana Burgos1Rebeca Pérez2Durvanei Augusto Maria3Paulo Pardi4Cristian Paz5Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, ChileDepartamento de Ciencias Biológicas y Químicas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Rudecindo Ortega, Temuco 02950, ChileLaboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, ChileDevelopment and Innovation Laboratory, Butantan Institute, Sao Paulo 1500, BrazilNucleo de Pesquisas NUPE/ENIAC University Center, Guarulhos 07012-030, BrazilLaboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, ChileBreast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface receptors, which makes treatment difficult. Epigallocatechin-3-gallate (EGCG) is a natural polyphenol isolated as the main component in green tea; it has shown multiple beneficial effects in breast cancer, controlling proliferation, invasion, apoptosis, inflammation, and demethylation of DNA. These properties were proved in vitro and in vivo together with synergistic effects in combination with traditional chemotherapy, increasing the effectiveness of the treatment. This review focuses on the effects of EGCG on the functional capabilities acquired by breast tumor cells during its multistep development, the molecular and signal pathways involved, the synergistic effects in combination with current drugs, and how nanomaterials can improve its bioavailability on breast cancer treatment.https://www.mdpi.com/1422-0067/24/13/10737epigallocatechin-3-gallatebreast cancersynergistic chemotherapymetabolismdrug delivery |
| spellingShingle | Víctor Marín Viviana Burgos Rebeca Pérez Durvanei Augusto Maria Paulo Pardi Cristian Paz The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment International Journal of Molecular Sciences epigallocatechin-3-gallate breast cancer synergistic chemotherapy metabolism drug delivery |
| title | The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment |
| title_full | The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment |
| title_fullStr | The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment |
| title_full_unstemmed | The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment |
| title_short | The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment |
| title_sort | potential role of epigallocatechin 3 gallate egcg in breast cancer treatment |
| topic | epigallocatechin-3-gallate breast cancer synergistic chemotherapy metabolism drug delivery |
| url | https://www.mdpi.com/1422-0067/24/13/10737 |
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