De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein

De novo Neurosteroidogenesis in Human Microglia: Involvement of the 18 kDa Translocator Protein

Neuroactive steroids are potent modulators of microglial functions and are capable of counteracting their excessive reactivity. This action has mainly been ascribed to neuroactive steroids released from other sources, as microglia have been defined unable to produce neurosteroids de novo. Unexpected...

Full description

Bibliographic Details
Main Authors:	Lorenzo Germelli, Eleonora Da Pozzo, Chiara Giacomelli, Chiara Tremolanti, Laura Marchetti, Christian H. Wetzel, Elisabetta Barresi, Sabrina Taliani, Federico Da Settimo, Claudia Martini, Barbara Costa
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	International Journal of Molecular Sciences
Subjects:	18 kDa TSPO human microglial cells neurosteroidogenesis neurosteroids CYP11A1 StAR protein
Online Access:	https://www.mdpi.com/1422-0067/22/6/3115

Similar Items

Neurosteroid biosynthesis and function in the brain of domestic birds
by: Kazuyoshi eTsutsui
Published: (2011-09-01)

Paeoniflorin elicits the anti-proliferative effects on glioma cell via targeting translocator protein 18 KDa
by: Zhuo-wei Gao, et al.
Published: (2021-01-01)

Targeting neurosteroidogenesis as therapy for PTSD
by: Graziano ePinna
Published: (2014-01-01)

The 18 kDa Translocator Protein (TSPO) Overexpression in Hippocampal Dentate Gyrus Elicits Anxiolytic-Like Effects in a Mouse Model of Post-traumatic Stress Disorder
by: Xiao-Ying Zhang, et al.
Published: (2018-11-01)

DE NOVO NEUROSTEROIDOGENESIS ENABLES CHOLESTEROL HOMEOSTASIS IN HUMAN MICROGLIA PRESERVING THEIR PROPER FUNCTIONALITY: CRUCIAL ROLE OF 18 KDA TRANSLOCATOR PROTEIN
by: Elisa Angeloni, et al.
Published: (2023-10-01)

Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers
by: Hendris Wongso, et al.
Published: (2024-03-01)

The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects
by: Benjamin B. Tournier, et al.
Published: (2022-01-01)

Translocator protein in the rise and fall of central nervous system neurons
by: Garett Cheung, et al.
Published: (2023-06-01)

TSPO: an emerging role in appetite for a therapeutically promising biomarker
by: Joshua Wang, et al.
Published: (2021-08-01)

Sex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals
by: Sini Laaksonen, et al.
Published: (2024-02-01)

A translocator protein 18 kDa agonist protects against cerebral ischemia/reperfusion injury
by: Han-Dong Li, et al.
Published: (2017-07-01)

The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions
by: Philippe Liere, et al.
Published: (2023-01-01)

Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells
by: Laura González-Blanco, et al.
Published: (2021-10-01)

Impact of Translocator Protein 18 kDa (TSPO) Deficiency on Mitochondrial Function and the Inflammatory State of Human C20 Microglia Cells
by: Stefanie Bader, et al.
Published: (2023-03-01)

In vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease
by: Romain Schollhammer, et al.
Published: (2021-05-01)

Translocator Protein 18 kDa (TSPO) Deficiency Inhibits Microglial Activation and Impairs Mitochondrial Function
by: Rumeng Yao, et al.
Published: (2020-06-01)

Multi-Targeted Neutron Capture Therapy Combined with an 18 kDa Translocator Protein-Targeted Boron Compound Is an Effective Strategy in a Rat Brain Tumor Model
by: Hideki Kashiwagi, et al.
Published: (2023-02-01)

Neurosteroids as neuromodulators in the treatment of anxiety disorders
by: Patrizia eLongone, et al.
Published: (2011-10-01)

Investigation of the Possible Allostery of Koumine Extracted From Gelsemium elegans Benth. And Analgesic Mechanism Associated With Neurosteroids
by: Bojun Xiong, et al.
Published: (2021-10-01)

Translocator protein 18 kDa regulates retinal neuron apoptosis and pyroptosis in glaucoma
by: Zhou Zeng, et al.
Published: (2023-07-01)

Concussion: Beyond the Cascade
by: Kiel D. Neumann, et al.
Published: (2023-08-01)

Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
by: Lorraine Weidner, et al.
Published: (2023-09-01)

Lentiviral-mediated overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus ameliorates LPS - induced cognitive impairment in mice
by: Wei Wang, et al.
Published: (2016-10-01)

18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse model
by: Laura M. Bartos, et al.
Published: (2022-10-01)

Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [18F]LW223 as a TSPO-targeted PET radioligand
by: Zhiqiang Tan, et al.
Published: (2023-03-01)

Recent developments on PET radiotracers for TSPO and their applications in neuroimaging
by: Lingling Zhang, et al.
Published: (2021-02-01)

Longitudinal 18F-VUIIS1008 PET imaging in a rat model of rheumatoid arthritis
by: Xinhui Su, et al.
Published: (2022-12-01)

The Role of Translocator Protein TSPO in Hallmarks of Glioblastoma
by: Laura-Marie Ammer, et al.
Published: (2020-10-01)

Local modulation of steroid action: rapid control of enzymatic activity
by: Thierry D Charlier, et al.
Published: (2015-03-01)

ASIC-E4: Interplay of Beta-Amyloid, Synaptic Density and Neuroinflammation in Cognitively Normal Volunteers With Three Levels of Genetic Risk for Late-Onset Alzheimer's Disease – Study Protocol and Baseline Characteristics
by: Anniina Snellman, et al.
Published: (2022-02-01)

Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression
by: Xu-bo Li, et al.
Published: (2018-03-01)

Neurofilament light-chain (NfL) and 18 kDa translocator protein in early psychosis and its putative high-risk
by: Kankana Nisha Aji, et al.
Published: (2024-05-01)

Editorial: Dysfunctional microglia in neurological disorders
by: Anup Bhusal, et al.
Published: (2023-01-01)

Human Microglia Synthesize Neurosteroids to Cope with Rotenone-Induced Oxidative Stress
by: Chiara Lucchi, et al.
Published: (2023-04-01)

The brain of teleost fish, a source and a target of sexual steroids
by: Nicolas eDiotel, et al.
Published: (2011-12-01)

Role of Translocator 18 KDa Ligands in the Activation of Leukotriene B4 Activated G-Protein Coupled Receptor and Toll Like Receptor-4 Pathways in Neutrophils
by: Léonard de Vinci Kanda Kupa, et al.
Published: (2017-10-01)

Microglia activation in a pediatric rabbit model of tuberculous meningitis
by: Elizabeth W. Tucker, et al.
Published: (2016-12-01)

Taming microglia: the promise of engineered microglia in treating neurological diseases
by: Echo Yongqi Luo, et al.
Published: (2024-01-01)

Translocator Protein Ligand Etifoxine Attenuates MPTP-Induced Neurotoxicity
by: Qi Tian, et al.
Published: (2022-05-01)

Impact of Cholesterol on the Stability of Monomeric and Dimeric Forms of the Translocator Protein TSPO: A Molecular Simulation Study
by: Zeineb Si Chaib, et al.
Published: (2020-09-01)