Two New Compounds from the Fungus <i>Xylaria nigripes</i>
In the process of discovering more neural-system-related bioactive compounds from <i>Xylaria nigripes</i>, xylariamino acid A (<b>1</b>), a new amino acid derivative, and a new isovaleric acid phenethyl ester (<b>2</b>) were isolated and identified. Their structur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/2/508 |
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| author | Hongping Long Siqian Zhou Lanqing Li Jing Li Jikai Liu |
| author_facet | Hongping Long Siqian Zhou Lanqing Li Jing Li Jikai Liu |
| author_sort | Hongping Long |
| collection | DOAJ |
| description | In the process of discovering more neural-system-related bioactive compounds from <i>Xylaria nigripes</i>, xylariamino acid A (<b>1</b>), a new amino acid derivative, and a new isovaleric acid phenethyl ester (<b>2</b>) were isolated and identified. Their structures and absolute configurations were determined by analyses of IR, HRESIMS, NMR spectroscopic data, and gauge-independent atomic orbital (GIAO) NMR calculation, as well as electronic circular dichroism (ECD) calculation. The isolated compounds were evaluated for their neuroprotective effects against damage to PC12 cells by oxygen and glucose deprivation (OGD). Compounds <b>1</b> and <b>2</b> can increase the viability of OGD-induced PC12 cells at all tested concentrations. Moreover, compound <b>2</b> (1 μmol L<sup>−1</sup>) can significantly reduce the percentage of apoptotic cells. |
| first_indexed | 2024-03-09T11:36:59Z |
| format | Article |
| id | doaj.art-6841d8bf17f949ffa4418cbc99d4c554 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:36:59Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6841d8bf17f949ffa4418cbc99d4c5542023-11-30T23:40:51ZengMDPI AGMolecules1420-30492023-01-0128250810.3390/molecules28020508Two New Compounds from the Fungus <i>Xylaria nigripes</i>Hongping Long0Siqian Zhou1Lanqing Li2Jing Li3Jikai Liu4The First Hospital of Hunan University of Chinese Medicine, Center for Medical Research and Innovation, Changsha 410007, ChinaThe First Hospital of Hunan University of Chinese Medicine, Center for Medical Research and Innovation, Changsha 410007, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaDepartment of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaIn the process of discovering more neural-system-related bioactive compounds from <i>Xylaria nigripes</i>, xylariamino acid A (<b>1</b>), a new amino acid derivative, and a new isovaleric acid phenethyl ester (<b>2</b>) were isolated and identified. Their structures and absolute configurations were determined by analyses of IR, HRESIMS, NMR spectroscopic data, and gauge-independent atomic orbital (GIAO) NMR calculation, as well as electronic circular dichroism (ECD) calculation. The isolated compounds were evaluated for their neuroprotective effects against damage to PC12 cells by oxygen and glucose deprivation (OGD). Compounds <b>1</b> and <b>2</b> can increase the viability of OGD-induced PC12 cells at all tested concentrations. Moreover, compound <b>2</b> (1 μmol L<sup>−1</sup>) can significantly reduce the percentage of apoptotic cells.https://www.mdpi.com/1420-3049/28/2/508<i>Xylaria nigripes</i>structural elucidationamino acidneuroprotective activities |
| spellingShingle | Hongping Long Siqian Zhou Lanqing Li Jing Li Jikai Liu Two New Compounds from the Fungus <i>Xylaria nigripes</i> Molecules <i>Xylaria nigripes</i> structural elucidation amino acid neuroprotective activities |
| title | Two New Compounds from the Fungus <i>Xylaria nigripes</i> |
| title_full | Two New Compounds from the Fungus <i>Xylaria nigripes</i> |
| title_fullStr | Two New Compounds from the Fungus <i>Xylaria nigripes</i> |
| title_full_unstemmed | Two New Compounds from the Fungus <i>Xylaria nigripes</i> |
| title_short | Two New Compounds from the Fungus <i>Xylaria nigripes</i> |
| title_sort | two new compounds from the fungus i xylaria nigripes i |
| topic | <i>Xylaria nigripes</i> structural elucidation amino acid neuroprotective activities |
| url | https://www.mdpi.com/1420-3049/28/2/508 |
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