Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors

New thiazolopyrimidine derivatives 2, 3a-d, 4a-c, 5, 6a-c, and 7a,b were synthesised. All prepared compounds were evaluated by MTT cytotoxicity assay against three human tumour cell lines. Compounds 3c, 3d, 4c, 6a, 6b, and 7b exhibited potent to strong anticancer activity that was nearly comparable...

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Hlavní autoři: Mona S. El-Zoghbi, Samiha A. El-Sebaey, Hanan A. AL-Ghulikah, Eman A. Sobh
Médium: Článek
Jazyk:English
Vydáno: Taylor & Francis Group 2023-12-01
Edice:Journal of Enzyme Inhibition and Medicinal Chemistry
Témata:
Topoisomerase II inhibitiors
thiazolopyrimidine
anticancer
cell cycle
apoptosis
On-line přístup:https://www.tandfonline.com/doi/10.1080/14756366.2023.2175209

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2175209

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