3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis
The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this ba...
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MDPI AG
2018-12-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/5/4/54 |
| _version_ | 1819041210819411968 |
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| author | Volodimir Ushenko Anton Sdobnov Anna Syvokorovskaya Alexander Dubolazov Oleh Vanchulyak Alexander Ushenko Yurii Ushenko Mykhailo Gorsky Maxim Sidor Alexander Bykov Igor Meglinski |
| author_facet | Volodimir Ushenko Anton Sdobnov Anna Syvokorovskaya Alexander Dubolazov Oleh Vanchulyak Alexander Ushenko Yurii Ushenko Mykhailo Gorsky Maxim Sidor Alexander Bykov Igor Meglinski |
| author_sort | Volodimir Ushenko |
| collection | DOAJ |
| description | The decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method—the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved. |
| first_indexed | 2024-12-21T09:21:23Z |
| format | Article |
| id | doaj.art-68455cf7e6674fe9881473d4b804ba3f |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-12-21T09:21:23Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-68455cf7e6674fe9881473d4b804ba3f2022-12-21T19:09:00ZengMDPI AGPhotonics2304-67322018-12-01545410.3390/photonics5040054photonics50400543D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer DiagnosisVolodimir Ushenko0Anton Sdobnov1Anna Syvokorovskaya2Alexander Dubolazov3Oleh Vanchulyak4Alexander Ushenko5Yurii Ushenko6Mykhailo Gorsky7Maxim Sidor8Alexander Bykov9Igor Meglinski10Optics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, UkraineOpto-Electronic and Measurement Techniques, University of Oulu, P. O. Box 4500, 90014 Oulu, FinlandDepartment of Forensic Medicine, Bukovinian State Medical University, 3 Theatral Sq., 58000 Chernivtsi, UkraineOptics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, UkraineDepartment of Forensic Medicine, Bukovinian State Medical University, 3 Theatral Sq., 58000 Chernivtsi, UkraineOptics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, UkraineOptics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, UkraineOptics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, UkraineOptics and Publishing Department, Chernivtsi National University, 2 Kotsiubynskyi Str., 58012 Chernivtsi, UkraineOpto-Electronic and Measurement Techniques, University of Oulu, P. O. Box 4500, 90014 Oulu, FinlandOpto-Electronic and Measurement Techniques, University of Oulu, P. O. Box 4500, 90014 Oulu, FinlandThe decomposition of the Mueller matrix of blood films has been carried out using differential matrices with polarized and depolarized parts. The use of a coherent reference wave is applied and the algorithm of digital holographic reconstruction of the field of complex amplitudes is used. On this basis, the 3D Mueller-matrix diffuse tomography method—the reconstruction of distributions of fluctuations of linear and circular birefringence of depolarizing polycrystalline films of human blood is analytically justified and experimentally tested. The dynamics of the change in the magnitude of the statistical moments of the first-fourth order, which characterize layer-by-layer distributions of fluctuations in the phase anisotropy of the blood film, is examined and analyzed. The most sensitive parameters for prostate cancer are the statistical moments of the third and fourth orders, which characterize the asymmetry and kurtosis of fluctuations in the linear and circular birefringence of blood films. The excellent accuracy of differentiation obtained polycrystalline films of blood from healthy donors and patients with cancer patients was achieved.https://www.mdpi.com/2304-6732/5/4/54Mueller-matrixpolarizationpolarimetrybloodcancer diagnostics |
| spellingShingle | Volodimir Ushenko Anton Sdobnov Anna Syvokorovskaya Alexander Dubolazov Oleh Vanchulyak Alexander Ushenko Yurii Ushenko Mykhailo Gorsky Maxim Sidor Alexander Bykov Igor Meglinski 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis Photonics Mueller-matrix polarization polarimetry blood cancer diagnostics |
| title | 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis |
| title_full | 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis |
| title_fullStr | 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis |
| title_full_unstemmed | 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis |
| title_short | 3D Mueller-Matrix Diffusive Tomography of Polycrystalline Blood Films for Cancer Diagnosis |
| title_sort | 3d mueller matrix diffusive tomography of polycrystalline blood films for cancer diagnosis |
| topic | Mueller-matrix polarization polarimetry blood cancer diagnostics |
| url | https://www.mdpi.com/2304-6732/5/4/54 |
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