Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89

Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89

ABSTRACT Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin. However, the molecular basis of their action is not fully understood. Here, we examined the genomic and transcriptome responses by Enterobacter hormaechei after prolo...

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Bibliographic Details
Main Authors: Suhanya V. Prasad, Krzysztof Fiedoruk, Magdalena Zakrzewska, Paul B. Savage, Robert Bucki
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
colistin
ceragenins
CSA-13
transcriptional regulation
adaptive resistance
next-generation sequencing
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01215-23

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