Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission
Abstract Evidence indicates that patients with chronic low back pain (CLBP) have lumbar multifidus muscle (LM) activation deficit which might be caused by changes in cortical excitability. Anodal transcranial direct current stimulation (a-tDCS) can be used to restore cortical excitability. This stud...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43597-7 |
| _version_ | 1797453210700480512 |
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| author | Peemongkon Wattananon Khin Win Thu Soniya Maharjan Kanphajee Sornkaew Hsing-Kuo Wang |
| author_facet | Peemongkon Wattananon Khin Win Thu Soniya Maharjan Kanphajee Sornkaew Hsing-Kuo Wang |
| author_sort | Peemongkon Wattananon |
| collection | DOAJ |
| description | Abstract Evidence indicates that patients with chronic low back pain (CLBP) have lumbar multifidus muscle (LM) activation deficit which might be caused by changes in cortical excitability. Anodal transcranial direct current stimulation (a-tDCS) can be used to restore cortical excitability. This study aimed to (1) determine the immediate effects of a-tDCS on the cortical excitability and LM activation and (2) explore the relationship between cortical excitability and LM activation. Thirteen participants with CLBP during remission and 11 healthy participants were recruited. Cortical excitability (peak-to-peak motor evoked potential amplitude; P2P and cortical silent period; CSP) and LM activation were measured at pre- and post-intervention. We found significant difference (P < 0.05) in P2P between groups. However, no significant differences (P > 0.05) in P2P, CSP and LM activation were found between pre- and post-intervention in CLBP. The CLBP group demonstrated significant correlation (P = 0.05) between P2P and LM activation. Although our finding demonstrates change in P2P in the CLBP group, one-session of a-tDCS cannot induce changes in cortical excitability and LM activation. However, moderate to strong correlation between P2P and LM activation suggests the involvement of cortical level in LM activation deficit. Therefore, non-significant changes could have been due to inadequate dose of a-tDCS. |
| first_indexed | 2024-03-09T15:19:30Z |
| format | Article |
| id | doaj.art-6846854d3f394cd3933a377d25ed7354 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:19:30Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6846854d3f394cd3933a377d25ed73542023-11-26T12:53:47ZengNature PortfolioScientific Reports2045-23222023-09-011311910.1038/s41598-023-43597-7Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remissionPeemongkon Wattananon0Khin Win Thu1Soniya Maharjan2Kanphajee Sornkaew3Hsing-Kuo Wang4Spine Biomechanics Laboratory, Faculty of Physical Therapy, Mahidol UniversitySpine Biomechanics Laboratory, Faculty of Physical Therapy, Mahidol UniversitySpine Biomechanics Laboratory, Faculty of Physical Therapy, Mahidol UniversityDepartment of Physical Therapy, Faculty of Allied Health Sciences, Naresuan UniversitySports Physiotherapy Lab, School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan UniversityAbstract Evidence indicates that patients with chronic low back pain (CLBP) have lumbar multifidus muscle (LM) activation deficit which might be caused by changes in cortical excitability. Anodal transcranial direct current stimulation (a-tDCS) can be used to restore cortical excitability. This study aimed to (1) determine the immediate effects of a-tDCS on the cortical excitability and LM activation and (2) explore the relationship between cortical excitability and LM activation. Thirteen participants with CLBP during remission and 11 healthy participants were recruited. Cortical excitability (peak-to-peak motor evoked potential amplitude; P2P and cortical silent period; CSP) and LM activation were measured at pre- and post-intervention. We found significant difference (P < 0.05) in P2P between groups. However, no significant differences (P > 0.05) in P2P, CSP and LM activation were found between pre- and post-intervention in CLBP. The CLBP group demonstrated significant correlation (P = 0.05) between P2P and LM activation. Although our finding demonstrates change in P2P in the CLBP group, one-session of a-tDCS cannot induce changes in cortical excitability and LM activation. However, moderate to strong correlation between P2P and LM activation suggests the involvement of cortical level in LM activation deficit. Therefore, non-significant changes could have been due to inadequate dose of a-tDCS.https://doi.org/10.1038/s41598-023-43597-7 |
| spellingShingle | Peemongkon Wattananon Khin Win Thu Soniya Maharjan Kanphajee Sornkaew Hsing-Kuo Wang Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission Scientific Reports |
| title | Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission |
| title_full | Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission |
| title_fullStr | Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission |
| title_full_unstemmed | Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission |
| title_short | Cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission |
| title_sort | cortical excitability and multifidus activation responses to transcranial direct current stimulation in patients with chronic low back pain during remission |
| url | https://doi.org/10.1038/s41598-023-43597-7 |
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