Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China
Background and Objectives: Studies examining the risk factors for dyskinesia in Parkinson's disease (PD) have been inconsistent, and racial differences exist. Since there have been no systematic studies of the characteristics of dyskinesia in the Mainland Chinese population, we sought to elucid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00477/full |
| _version_ | 1818149109369929728 |
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| author | Xun Zhou Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Qiying Sun Qiying Sun Qiying Sun Qian Xu Qian Xu Qian Xu Hongxu Pan Renhe Yu Jieqiong Tan Xinxiang Yan Xinxiang Yan Xinxiang Yan Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Liangjuan Fang Liangjuan Fang Liangjuan Fang |
| author_facet | Xun Zhou Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Qiying Sun Qiying Sun Qiying Sun Qian Xu Qian Xu Qian Xu Hongxu Pan Renhe Yu Jieqiong Tan Xinxiang Yan Xinxiang Yan Xinxiang Yan Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Liangjuan Fang Liangjuan Fang Liangjuan Fang |
| author_sort | Xun Zhou |
| collection | DOAJ |
| description | Background and Objectives: Studies examining the risk factors for dyskinesia in Parkinson's disease (PD) have been inconsistent, and racial differences exist. Since there have been no systematic studies of the characteristics of dyskinesia in the Mainland Chinese population, we sought to elucidate the risk factors for dyskinesia.Methods: A total of 1974 PD patients from Mainland China were systematically investigated by univariable and multivariable analyses. PD patients with and without dyskinesia were stratified into 4 groups according to levodopa equivalent daily dose (LEDD) and analyzed by a Cox proportional hazards model. A longitudinal study of 87 patients with dyskinesia was classified into 3 groups according to the duration from onset of PD to the initiation of levodopa, and comparisons among groups were analyzed by the Mann-Whitney test.Results: Early age of onset, long disease duration, being female, high LEDD, low UPDRS III scores (ON-state) and high Hoehn-Yahr stage (ON-state) were predictors of dyskinesia. Dyskinesia was levodopa dosage-dependent, and the incidence increased remarkably when LEDD exceeded 300 mg/d (p < 0.05). The emergence of dyskinesia had no association with the initiation time of levodopa, and if the latter was more than 4 years, the duration of time on chronic levodopa free of motor complications was significantly shortened.Conclusions: We found risk factors for the prediction of dyskinesia. Our data shows that physicians should be cautious if the LEDD exceeds 300 mg/d. The development of dyskinesia was not correlated with the time of levodopa initiation. |
| first_indexed | 2024-12-11T13:01:48Z |
| format | Article |
| id | doaj.art-6846bfabdd6245d69d4eb74f553db33b |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-11T13:01:48Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6846bfabdd6245d69d4eb74f553db33b2022-12-22T01:06:27ZengFrontiers Media S.A.Frontiers in Neurology1664-22952019-05-011010.3389/fneur.2019.00477435261Factors Associated With Dyskinesia in Parkinson's Disease in Mainland ChinaXun Zhou0Jifeng Guo1Jifeng Guo2Jifeng Guo3Jifeng Guo4Jifeng Guo5Qiying Sun6Qiying Sun7Qiying Sun8Qian Xu9Qian Xu10Qian Xu11Hongxu Pan12Renhe Yu13Jieqiong Tan14Xinxiang Yan15Xinxiang Yan16Xinxiang Yan17Beisha Tang18Beisha Tang19Beisha Tang20Beisha Tang21Beisha Tang22Beisha Tang23Liangjuan Fang24Liangjuan Fang25Liangjuan Fang26Department of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaLaboratory of Medical Genetics, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaCenter for Brain Disorders Research, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaSchool of Public Health, Central South University, Changsha, ChinaLaboratory of Medical Genetics, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaLaboratory of Medical Genetics, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaCenter for Brain Disorders Research, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, ChinaDepartment of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaBackground and Objectives: Studies examining the risk factors for dyskinesia in Parkinson's disease (PD) have been inconsistent, and racial differences exist. Since there have been no systematic studies of the characteristics of dyskinesia in the Mainland Chinese population, we sought to elucidate the risk factors for dyskinesia.Methods: A total of 1974 PD patients from Mainland China were systematically investigated by univariable and multivariable analyses. PD patients with and without dyskinesia were stratified into 4 groups according to levodopa equivalent daily dose (LEDD) and analyzed by a Cox proportional hazards model. A longitudinal study of 87 patients with dyskinesia was classified into 3 groups according to the duration from onset of PD to the initiation of levodopa, and comparisons among groups were analyzed by the Mann-Whitney test.Results: Early age of onset, long disease duration, being female, high LEDD, low UPDRS III scores (ON-state) and high Hoehn-Yahr stage (ON-state) were predictors of dyskinesia. Dyskinesia was levodopa dosage-dependent, and the incidence increased remarkably when LEDD exceeded 300 mg/d (p < 0.05). The emergence of dyskinesia had no association with the initiation time of levodopa, and if the latter was more than 4 years, the duration of time on chronic levodopa free of motor complications was significantly shortened.Conclusions: We found risk factors for the prediction of dyskinesia. Our data shows that physicians should be cautious if the LEDD exceeds 300 mg/d. The development of dyskinesia was not correlated with the time of levodopa initiation.https://www.frontiersin.org/article/10.3389/fneur.2019.00477/fullParkinson's diseaselevodopadyskinesiarisk factorsdisease duration |
| spellingShingle | Xun Zhou Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Qiying Sun Qiying Sun Qiying Sun Qian Xu Qian Xu Qian Xu Hongxu Pan Renhe Yu Jieqiong Tan Xinxiang Yan Xinxiang Yan Xinxiang Yan Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Liangjuan Fang Liangjuan Fang Liangjuan Fang Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China Frontiers in Neurology Parkinson's disease levodopa dyskinesia risk factors disease duration |
| title | Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China |
| title_full | Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China |
| title_fullStr | Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China |
| title_full_unstemmed | Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China |
| title_short | Factors Associated With Dyskinesia in Parkinson's Disease in Mainland China |
| title_sort | factors associated with dyskinesia in parkinson s disease in mainland china |
| topic | Parkinson's disease levodopa dyskinesia risk factors disease duration |
| url | https://www.frontiersin.org/article/10.3389/fneur.2019.00477/full |
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