Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study
Introduction: Most studies investigate sexual dysfunction in drug abusers; however, there are no data available about the pattern of drug abuse in patients with lifelong premature ejaculation (PE). Aim: To assess the pattern of drug abuse in patients with lifelong PE and to evaluate its potential ef...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2020-12-01
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| Series: | Sexual Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2050116120301185 |
| _version_ | 1797722337466908672 |
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| author | Soheir A. Mohammed, MD Amr Abdelhamed, MD, FECSM Reda M. El Sayed, MD |
| author_facet | Soheir A. Mohammed, MD Amr Abdelhamed, MD, FECSM Reda M. El Sayed, MD |
| author_sort | Soheir A. Mohammed, MD |
| collection | DOAJ |
| description | Introduction: Most studies investigate sexual dysfunction in drug abusers; however, there are no data available about the pattern of drug abuse in patients with lifelong premature ejaculation (PE). Aim: To assess the pattern of drug abuse in patients with lifelong PE and to evaluate its potential effect on their hormonal profile. Methods: A cross-sectional study included patients with lifelong PE (n = 76) with no prescribed medications for 1 month and age-matched control without PE (n = 48). Participants were evaluated by history, examination, Arabic index of PE, and hormonal profile. A urine sample was screened by dipstick kits for the following drug abuse tramadol, opiate, tetrahydrocannabinol (cannabis), amphetamine, barbiturate, cocaine, and benzodiazepines. Positive results were confirmed with a immunoassay drug analyzer. Main outcome measures: The outcomes of this study are positive and negative drug abuse and hormonal profile changes. Results: Control patients and patients with PE showed median (interquartile range) of age 43 (33–46.8) and 38.5 (31–45) years, respectively. Drug abuse testing results showed significantly high positive drug abuse in patients with PE, 26 of 76 (34.2%), in comparison with control, 9 of 48 (19.1%) (P = .05). The most commonly abused drug was tetrahydrocannabinol in control, 3 of 9 (33.3%), and tramadol, 12 of 26 (46.2%), in patients with PE. Control patients and patients with PE with positive drug abuse had significantly higher smoking percent (P < .0001) and higher positive drug abuse history (P < .0001). However, there was no relationship between drug abuse and PE severity, and there were no significant changes in their hormonal profile. Conclusions: Drug abuse is high among patients with lifelong PE in Upper Egypt, with tramadol being the comment drug. Drug abuse is common among smokers. However, no hormonal disturbance could be shown in drug abuse patients. Drug abuse might be considered in the evaluation of patients with PE.Mohammed SA, Abdelhamed A, El Sayed RM. Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study. Sex Med 2020;8:608–614. |
| first_indexed | 2024-03-12T09:47:08Z |
| format | Article |
| id | doaj.art-68471fd2b0934277b94a893121dbffa8 |
| institution | Directory Open Access Journal |
| issn | 2050-1161 |
| language | English |
| last_indexed | 2024-03-12T09:47:08Z |
| publishDate | 2020-12-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Sexual Medicine |
| spelling | doaj.art-68471fd2b0934277b94a893121dbffa82023-09-02T12:49:19ZengOxford University PressSexual Medicine2050-11612020-12-0184608614Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional StudySoheir A. Mohammed, MD0Amr Abdelhamed, MD, FECSM1Reda M. El Sayed, MD2Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Sohag University, Sohag, EgyptDermatology, Venereology and Andrology Department, Faculty of Medicine, Sohag University, Sohag, Egypt; Corresponding Author: Amr Abdelhamed, MD, FECSM, Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt. Tel: +201005825574; Fax: +20934602963Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Sohag University, Sohag, EgyptIntroduction: Most studies investigate sexual dysfunction in drug abusers; however, there are no data available about the pattern of drug abuse in patients with lifelong premature ejaculation (PE). Aim: To assess the pattern of drug abuse in patients with lifelong PE and to evaluate its potential effect on their hormonal profile. Methods: A cross-sectional study included patients with lifelong PE (n = 76) with no prescribed medications for 1 month and age-matched control without PE (n = 48). Participants were evaluated by history, examination, Arabic index of PE, and hormonal profile. A urine sample was screened by dipstick kits for the following drug abuse tramadol, opiate, tetrahydrocannabinol (cannabis), amphetamine, barbiturate, cocaine, and benzodiazepines. Positive results were confirmed with a immunoassay drug analyzer. Main outcome measures: The outcomes of this study are positive and negative drug abuse and hormonal profile changes. Results: Control patients and patients with PE showed median (interquartile range) of age 43 (33–46.8) and 38.5 (31–45) years, respectively. Drug abuse testing results showed significantly high positive drug abuse in patients with PE, 26 of 76 (34.2%), in comparison with control, 9 of 48 (19.1%) (P = .05). The most commonly abused drug was tetrahydrocannabinol in control, 3 of 9 (33.3%), and tramadol, 12 of 26 (46.2%), in patients with PE. Control patients and patients with PE with positive drug abuse had significantly higher smoking percent (P < .0001) and higher positive drug abuse history (P < .0001). However, there was no relationship between drug abuse and PE severity, and there were no significant changes in their hormonal profile. Conclusions: Drug abuse is high among patients with lifelong PE in Upper Egypt, with tramadol being the comment drug. Drug abuse is common among smokers. However, no hormonal disturbance could be shown in drug abuse patients. Drug abuse might be considered in the evaluation of patients with PE.Mohammed SA, Abdelhamed A, El Sayed RM. Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study. Sex Med 2020;8:608–614.http://www.sciencedirect.com/science/article/pii/S2050116120301185Drug AbuseLifelong Premature EjaculationTramadol AbuseMale Hormonal Profile |
| spellingShingle | Soheir A. Mohammed, MD Amr Abdelhamed, MD, FECSM Reda M. El Sayed, MD Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study Sexual Medicine Drug Abuse Lifelong Premature Ejaculation Tramadol Abuse Male Hormonal Profile |
| title | Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study |
| title_full | Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study |
| title_fullStr | Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study |
| title_full_unstemmed | Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study |
| title_short | Evaluation of Drug Abuse in Patients With Lifelong Premature Ejaculation: A Cross-Sectional Study |
| title_sort | evaluation of drug abuse in patients with lifelong premature ejaculation a cross sectional study |
| topic | Drug Abuse Lifelong Premature Ejaculation Tramadol Abuse Male Hormonal Profile |
| url | http://www.sciencedirect.com/science/article/pii/S2050116120301185 |
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