Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma

Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma

Ferroptosis, a newly defined and iron-dependent cell death, morphologically and biochemically differs from other cell deaths. Melanoma is a serious type of skin cancer, and the poor efficacy of current therapies causes a major increase in mortality. Sorafenib, a multiple kinase inhibitor, has been e...

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Bibliographic Details
Main Authors: Yu Yi, Ren Yuanyuan, Wang Caihua, Li Zhuozhuo, Niu Fanglin, Li Zi, Ye Qiang, Wang Jiangxia, Yan Yuan, Liu Ping, Qian Lu, Xiong Yuyan
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
Arginase 2
sorafenib
ferroptosis
lipid peroxidation
melanoma
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022166

Internet

https://www.sciengine.com/doi/10.3724/abbs.2022166

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