BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy

BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy

Abstract Dysregulation of circadian rhythms associates with cardiovascular disorders. It is known that deletion of the core circadian gene Bmal1 in mice causes dilated cardiomyopathy. However, the biological rhythm regulation system in mouse is very different from that of humans. Whether BMAL1 plays...

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Bibliographic Details
Main Authors: Ermin Li, Xiuya Li, Jie Huang, Chen Xu, Qianqian Liang, Kehan Ren, Aobing Bai, Chao Lu, Ruizhe Qian, Ning Sun
Format: Article
Language:English
Published: Oxford University Press 2020-04-01
Series:Protein & Cell
Subjects:
circadian gene BMAL1
human embryonic stem cells
cell differentiation
cardiomyocytes
dilated cardiomyopathy
mitochondria
Online Access:https://doi.org/10.1007/s13238-020-00713-x

Internet

https://doi.org/10.1007/s13238-020-00713-x

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