Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacy
Despite progress in the treatment of spinal cord injury (SCI), recovery of the spinal cord with normal motor and sensory activities remains a challenge due to the complex anatomy of the spine, and its limited regeneration potential in mammals. Recently, the clinical application of mesenchymal stem...
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| Format: | Article |
| Language: | English |
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Indian Council of Agricultural Research
2022-07-01
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| Series: | Indian Journal of Animal Sciences |
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| Online Access: | https://epubs.icar.org.in/index.php/IJAnS/article/view/119081 |
| _version_ | 1811169057515241472 |
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| author | BHABESH MILI LUKUMONI BURAGOHAIN LALCHAWIMAWIA RALTE TUKHESWAR CHUTIA AMRIT GOGOI UTPAL BARMAN |
| author_facet | BHABESH MILI LUKUMONI BURAGOHAIN LALCHAWIMAWIA RALTE TUKHESWAR CHUTIA AMRIT GOGOI UTPAL BARMAN |
| author_sort | BHABESH MILI |
| collection | DOAJ |
| description |
Despite progress in the treatment of spinal cord injury (SCI), recovery of the spinal cord with normal motor and
sensory activities remains a challenge due to the complex anatomy of the spine, and its limited regeneration potential in mammals. Recently, the clinical application of mesenchymal stem cells (MSCs) in SCI led to promising results in both human and veterinary medicine. The mechanism by which MSCs might promote wound healing of SCI has been extensively investigated. Previous reports have suggested that transplanted MSCs enhance the numbers of neurons and glial cells, prevent neuronal apoptosis, inhibit inflammation, stimulate vascular angiogenesis, axonal myelination, and neuro-regeneration at the lesion site. It has also been reported that therapeutic applicability depends on the source of derivation of MSCs and their differentiation capability into specific cell lineages at the transplanted site. Therefore, this review is focussed on precise mechanisms by which transplantation of MSCs promote functional recovery and also addresses the challenges to improve the therapeutic efficacy of MSCs for treating SCI in dogs.
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| first_indexed | 2024-04-10T16:36:44Z |
| format | Article |
| id | doaj.art-6848114a64784e408f3cf470c8ba5522 |
| institution | Directory Open Access Journal |
| issn | 0367-8318 2394-3327 |
| language | English |
| last_indexed | 2024-04-10T16:36:44Z |
| publishDate | 2022-07-01 |
| publisher | Indian Council of Agricultural Research |
| record_format | Article |
| series | Indian Journal of Animal Sciences |
| spelling | doaj.art-6848114a64784e408f3cf470c8ba55222023-02-08T11:23:16ZengIndian Council of Agricultural ResearchIndian Journal of Animal Sciences0367-83182394-33272022-07-0192710.56093/ijans.v92i7.119081Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacyBHABESH MILI0LUKUMONI BURAGOHAIN1LALCHAWIMAWIA RALTE2TUKHESWAR CHUTIA3AMRIT GOGOI4UTPAL BARMAN5College of Veterinary Sciences and Animal Husbandry Central Agricultural University (I)Jalukie Peren Dist., Nagaland 797110Central Agricultural University (I), Jalukie, Peren, Nagaland 797 110 IndiaCentral Agricultural University (I), Jalukie, Peren, Nagaland 797 110 IndiaCentral Agricultural University (I), Jalukie, Peren, Nagaland 797 110 IndiaCentral Agricultural University (I), Jalukie, Peren, Nagaland 797 110 IndiaCentral Agricultural University (I), Jalukie, Peren, Nagaland 797 110 India Despite progress in the treatment of spinal cord injury (SCI), recovery of the spinal cord with normal motor and sensory activities remains a challenge due to the complex anatomy of the spine, and its limited regeneration potential in mammals. Recently, the clinical application of mesenchymal stem cells (MSCs) in SCI led to promising results in both human and veterinary medicine. The mechanism by which MSCs might promote wound healing of SCI has been extensively investigated. Previous reports have suggested that transplanted MSCs enhance the numbers of neurons and glial cells, prevent neuronal apoptosis, inhibit inflammation, stimulate vascular angiogenesis, axonal myelination, and neuro-regeneration at the lesion site. It has also been reported that therapeutic applicability depends on the source of derivation of MSCs and their differentiation capability into specific cell lineages at the transplanted site. Therefore, this review is focussed on precise mechanisms by which transplantation of MSCs promote functional recovery and also addresses the challenges to improve the therapeutic efficacy of MSCs for treating SCI in dogs. https://epubs.icar.org.in/index.php/IJAnS/article/view/119081Central Nervous System (CNS)DogMesenchymal Stem Cells (MSCs)neurotrophic factorsSpinal Cord Injury (SCI). |
| spellingShingle | BHABESH MILI LUKUMONI BURAGOHAIN LALCHAWIMAWIA RALTE TUKHESWAR CHUTIA AMRIT GOGOI UTPAL BARMAN Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacy Indian Journal of Animal Sciences Central Nervous System (CNS) Dog Mesenchymal Stem Cells (MSCs) neurotrophic factors Spinal Cord Injury (SCI). |
| title | Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacy |
| title_full | Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacy |
| title_fullStr | Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacy |
| title_full_unstemmed | Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacy |
| title_short | Application of mesenchymal stem cells for treating spinal cord injury in dogs: Mechanisms and their therapeutic efficacy |
| title_sort | application of mesenchymal stem cells for treating spinal cord injury in dogs mechanisms and their therapeutic efficacy |
| topic | Central Nervous System (CNS) Dog Mesenchymal Stem Cells (MSCs) neurotrophic factors Spinal Cord Injury (SCI). |
| url | https://epubs.icar.org.in/index.php/IJAnS/article/view/119081 |
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