Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management
Neurodegeneration with brain iron accumulation (NBIA) encompasses a group of inherited disorders that share the clinical features of an extrapyramidal movement disorder accompanied by varying degrees of intellectual disability and abnormal iron deposition in the basal ganglia. The genetic basis of t...
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| Format: | Article |
| Language: | English |
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Korean Movement Disorder Society
2015-01-01
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| Series: | Journal of Movement Disorders |
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| Online Access: | http://e-jmd.org/upload/jmd-8-1-1.pdf |
| _version_ | 1797716052259373056 |
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| author | Penelope Hogarth |
| author_facet | Penelope Hogarth |
| author_sort | Penelope Hogarth |
| collection | DOAJ |
| description | Neurodegeneration with brain iron accumulation (NBIA) encompasses a group of inherited disorders that share the clinical features of an extrapyramidal movement disorder accompanied by varying degrees of intellectual disability and abnormal iron deposition in the basal ganglia. The genetic basis of ten forms of NBIA is now known. The clinical features of NBIA range from rapid global neurodevelopmental regression in infancy to mild parkinsonism with minimal cognitive impairment in adulthood, with wide variation seen between and within the specific NBIA sub-type. This review describes the clinical presentations, imaging findings, pathologic features, and treatment considerations for this heterogeneous group of disorders. |
| first_indexed | 2024-03-12T08:15:48Z |
| format | Article |
| id | doaj.art-684852d27a1f4f3bb67e0c154f35ffce |
| institution | Directory Open Access Journal |
| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:15:48Z |
| publishDate | 2015-01-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-684852d27a1f4f3bb67e0c154f35ffce2023-09-02T18:53:33ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392015-01-018111310.14802/jmd.14034123Neurodegeneration with Brain Iron Accumulation: Diagnosis and ManagementPenelope HogarthNeurodegeneration with brain iron accumulation (NBIA) encompasses a group of inherited disorders that share the clinical features of an extrapyramidal movement disorder accompanied by varying degrees of intellectual disability and abnormal iron deposition in the basal ganglia. The genetic basis of ten forms of NBIA is now known. The clinical features of NBIA range from rapid global neurodevelopmental regression in infancy to mild parkinsonism with minimal cognitive impairment in adulthood, with wide variation seen between and within the specific NBIA sub-type. This review describes the clinical presentations, imaging findings, pathologic features, and treatment considerations for this heterogeneous group of disorders.http://e-jmd.org/upload/jmd-8-1-1.pdfNeurodegenerative diseasesIronNeuroaxonal dystrophiesPantothenate kinase associated neurodegenerationIron metabolism disordersBrain diseasesmetabolicinborn |
| spellingShingle | Penelope Hogarth Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management Journal of Movement Disorders Neurodegenerative diseases Iron Neuroaxonal dystrophies Pantothenate kinase associated neurodegeneration Iron metabolism disorders Brain diseases metabolic inborn |
| title | Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management |
| title_full | Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management |
| title_fullStr | Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management |
| title_full_unstemmed | Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management |
| title_short | Neurodegeneration with Brain Iron Accumulation: Diagnosis and Management |
| title_sort | neurodegeneration with brain iron accumulation diagnosis and management |
| topic | Neurodegenerative diseases Iron Neuroaxonal dystrophies Pantothenate kinase associated neurodegeneration Iron metabolism disorders Brain diseases metabolic inborn |
| url | http://e-jmd.org/upload/jmd-8-1-1.pdf |
| work_keys_str_mv | AT penelopehogarth neurodegenerationwithbrainironaccumulationdiagnosisandmanagement |