Construction and Evaluation of Animal Models for Cerebral Ischemia
Cerebral ischemia is a common clinical cerebrovascular disease, accounting for about 80% of all cerebrovascular diseases, and it is mainly caused by insufficient blood supply to the cerebrovascular system. Multiple animal models have currently been used to study the pathogenesis and treatment of cer...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Laboratory Animal and Comparative Medicine
2021-08-01
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| Series: | Shiyan dongwu yu bijiao yixue |
| Subjects: | |
| Online Access: | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.085 |
| _version_ | 1828183145842737152 |
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| author | HU Zhibin HUANG Ying DING Yuqiang |
| author_facet | HU Zhibin HUANG Ying DING Yuqiang |
| author_sort | HU Zhibin |
| collection | DOAJ |
| description | Cerebral ischemia is a common clinical cerebrovascular disease, accounting for about 80% of all cerebrovascular diseases, and it is mainly caused by insufficient blood supply to the cerebrovascular system. Multiple animal models have currently been used to study the pathogenesis and treatment of cerebral ischemia. In order to provide a reference for the selection and improvement of animal models for exploration of underlying mechanisms, this review highlights multiple animal models on global and focal cerebral ischemia with diagrams, and discusses their advantages and disadvantages. The choice of animals, behavioral evaluations of rodent sensory-motor activities, and histological evaluation progress for cerebral ischemia models are also outlined. |
| first_indexed | 2024-04-12T06:28:08Z |
| format | Article |
| id | doaj.art-684b3739e9b141fda954f8869aad94e3 |
| institution | Directory Open Access Journal |
| issn | 1674-5817 |
| language | zho |
| last_indexed | 2024-04-12T06:28:08Z |
| publishDate | 2021-08-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj.art-684b3739e9b141fda954f8869aad94e32022-12-22T03:44:05ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172021-08-0141427128310.12300/j.issn.1674-5817.2021.0851674-5817（2021）04-0271-13Construction and Evaluation of Animal Models for Cerebral IschemiaHU Zhibin0HUANG Ying1DING Yuqiang2Department of Laboratory Animal Science, Fudan University, Shanghai 200032, ChinaDepartment of Laboratory Animal Science, Fudan University, Shanghai 200032, ChinaDepartment of Laboratory Animal Science, Fudan University, Shanghai 200032, ChinaCerebral ischemia is a common clinical cerebrovascular disease, accounting for about 80% of all cerebrovascular diseases, and it is mainly caused by insufficient blood supply to the cerebrovascular system. Multiple animal models have currently been used to study the pathogenesis and treatment of cerebral ischemia. In order to provide a reference for the selection and improvement of animal models for exploration of underlying mechanisms, this review highlights multiple animal models on global and focal cerebral ischemia with diagrams, and discusses their advantages and disadvantages. The choice of animals, behavioral evaluations of rodent sensory-motor activities, and histological evaluation progress for cerebral ischemia models are also outlined.https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.085cerebral ischemiaanimal modelsensory-motor behavior |
| spellingShingle | HU Zhibin HUANG Ying DING Yuqiang Construction and Evaluation of Animal Models for Cerebral Ischemia Shiyan dongwu yu bijiao yixue cerebral ischemia animal model sensory-motor behavior |
| title | Construction and Evaluation of Animal Models for Cerebral Ischemia |
| title_full | Construction and Evaluation of Animal Models for Cerebral Ischemia |
| title_fullStr | Construction and Evaluation of Animal Models for Cerebral Ischemia |
| title_full_unstemmed | Construction and Evaluation of Animal Models for Cerebral Ischemia |
| title_short | Construction and Evaluation of Animal Models for Cerebral Ischemia |
| title_sort | construction and evaluation of animal models for cerebral ischemia |
| topic | cerebral ischemia animal model sensory-motor behavior |
| url | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.085 |
| work_keys_str_mv | AT huzhibin constructionandevaluationofanimalmodelsforcerebralischemia AT huangying constructionandevaluationofanimalmodelsforcerebralischemia AT dingyuqiang constructionandevaluationofanimalmodelsforcerebralischemia |