Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical Care
Background: Given that wheezing is treated with inhaled β2-agonists, their effect should be reviewed before the condition becomes severe; however, few methods can currently predict reactivity to inhaled β2-agonists. We investigated whether preinhalation wheezing characteristics identified by lung so...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2021.667094/full |
| _version_ | 1818668342219636736 |
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| author | Chizu Habukawa Naoto Ohgami Takahiro Arai Haruyuki Makata Tomoki Nishikido Morimitsu Tomikawa Katsumi Murakami |
| author_facet | Chizu Habukawa Naoto Ohgami Takahiro Arai Haruyuki Makata Tomoki Nishikido Morimitsu Tomikawa Katsumi Murakami |
| author_sort | Chizu Habukawa |
| collection | DOAJ |
| description | Background: Given that wheezing is treated with inhaled β2-agonists, their effect should be reviewed before the condition becomes severe; however, few methods can currently predict reactivity to inhaled β2-agonists. We investigated whether preinhalation wheezing characteristics identified by lung sound analysis can predict reactivity to inhaled β2-agonists.Methods: In 202 children aged 10–153 months, wheezing was identified by auscultation. Lung sounds were recorded for 30 s in the chest region on the chest wall during tidal breathing. We analyzed the wheezing before and after β2-agonist inhalation. Wheezing was displayed as horizontal bars of intensity defined as a wheeze power band, and the wheezing characteristics (number, frequency, and maximum intensity frequency) were evaluated by lung sound analysis. The participants were divided into two groups: non-disappears (wheezing did not disappear after inhalation) and disappears (wheezing disappeared after inhalation). Wheezing characteristics before β2-agonist inhalation were compared between the two groups.The characteristics of wheezing were not affected by body size. The number of wheeze power bands of the non-responder group was significantly higher than those of the responder group (P < 0.001). The number of wheeze power bands was a predictor of reactivity to inhaled β2-agonists, with a cutoff of 11.1. The 95% confidence intervals of sensitivity, specificity, and positive and negative predictive values were 88.8, 42, 44, and 81.1% (P < 0.001), respectively.Conclusions: The number of preinhalation wheeze power bands shown by lung sound analysis was a useful indicator before treatment. This indicator could be a beneficial index for managing wheezing in young children. |
| first_indexed | 2024-12-17T06:34:48Z |
| format | Article |
| id | doaj.art-684b3caaf3a343d68c2f99af866c5982 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-17T06:34:48Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-684b3caaf3a343d68c2f99af866c59822022-12-21T22:00:03ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602021-10-01910.3389/fped.2021.667094667094Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical CareChizu Habukawa0Naoto Ohgami1Takahiro Arai2Haruyuki Makata3Tomoki Nishikido4Morimitsu Tomikawa5Katsumi Murakami6Department of Pediatrics, Minami Wakayama Medical Center, Tanabe, JapanTechnology Development HQ, Omron Healthcare Co., Ltd., Muko, JapanArai Pediatric Clinic, Yamagata, JapanMakata Pediatrics and Allergy Clinic, Yamaguchi, JapanOsaka Women's and Children's Hospital, Izumi, JapanOdasaga Pediatrics and Allergy, Sagamihara, JapanDepartment of Psychosomatic Medicine, Sakai Sakibana Hospital, Sakai, JapanBackground: Given that wheezing is treated with inhaled β2-agonists, their effect should be reviewed before the condition becomes severe; however, few methods can currently predict reactivity to inhaled β2-agonists. We investigated whether preinhalation wheezing characteristics identified by lung sound analysis can predict reactivity to inhaled β2-agonists.Methods: In 202 children aged 10–153 months, wheezing was identified by auscultation. Lung sounds were recorded for 30 s in the chest region on the chest wall during tidal breathing. We analyzed the wheezing before and after β2-agonist inhalation. Wheezing was displayed as horizontal bars of intensity defined as a wheeze power band, and the wheezing characteristics (number, frequency, and maximum intensity frequency) were evaluated by lung sound analysis. The participants were divided into two groups: non-disappears (wheezing did not disappear after inhalation) and disappears (wheezing disappeared after inhalation). Wheezing characteristics before β2-agonist inhalation were compared between the two groups.The characteristics of wheezing were not affected by body size. The number of wheeze power bands of the non-responder group was significantly higher than those of the responder group (P < 0.001). The number of wheeze power bands was a predictor of reactivity to inhaled β2-agonists, with a cutoff of 11.1. The 95% confidence intervals of sensitivity, specificity, and positive and negative predictive values were 88.8, 42, 44, and 81.1% (P < 0.001), respectively.Conclusions: The number of preinhalation wheeze power bands shown by lung sound analysis was a useful indicator before treatment. This indicator could be a beneficial index for managing wheezing in young children.https://www.frontiersin.org/articles/10.3389/fped.2021.667094/fullwheezingyoung childrenlung sound analysisβ2-agonistswheeze analysis |
| spellingShingle | Chizu Habukawa Naoto Ohgami Takahiro Arai Haruyuki Makata Tomoki Nishikido Morimitsu Tomikawa Katsumi Murakami Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical Care Frontiers in Pediatrics wheezing young children lung sound analysis β2-agonists wheeze analysis |
| title | Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical Care |
| title_full | Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical Care |
| title_fullStr | Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical Care |
| title_full_unstemmed | Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical Care |
| title_short | Wheezing Characteristics and Predicting Reactivity to Inhaled β2-Agonist in Children for Home Medical Care |
| title_sort | wheezing characteristics and predicting reactivity to inhaled β2 agonist in children for home medical care |
| topic | wheezing young children lung sound analysis β2-agonists wheeze analysis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2021.667094/full |
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