The potential mechanisms of cardiovascular calcification in patients with chronic kidney disease
Based on current literature data, the important potential role of calciprotein particles, matrix vesicles, and extracellular matrix degradation in cardiovascular calcification mechanisms in chronic kidney disease (CKD) can be confirmed. The involvement of advanced glycation end products, insulin re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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State Institution «Institute of Nephrology NAMS of Ukraine"
2022-11-01
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| Series: | Український Журнал Нефрології та Діалізу |
| Subjects: | |
| Online Access: | https://ukrjnd.com.ua/index.php/journal/article/view/673 |
| _version_ | 1797262242208546816 |
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| author | O. Susla O. Bushtynska I. Yakubyshyna L. Logoyda K. Symko I. Mysula |
| author_facet | O. Susla O. Bushtynska I. Yakubyshyna L. Logoyda K. Symko I. Mysula |
| author_sort | O. Susla |
| collection | DOAJ |
| description |
Based on current literature data, the important potential role of calciprotein particles, matrix vesicles, and extracellular matrix degradation in cardiovascular calcification mechanisms in chronic kidney disease (CKD) can be confirmed. The involvement of advanced glycation end products, insulin resistance, microRNAs, iron metabolism disorders, fluid overload, and hemodialysis treatment in these processes is discussed. It was concluded that the above potential mechanisms of ectopic calcification, which are being actively explored, are directly or indirectly related to endothelial damage/dysfunction and metabolic disturbances in the nitric oxide system. It was concluded that further thorough scientific investigations and close collaboration between clinical and experimental nephrologists are useful to optimize programs for the early detection of cardiovascular calcification, develop new effective therapeutic strategies, and improve the prognosis of CKD patients.
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| first_indexed | 2024-04-24T23:54:00Z |
| format | Article |
| id | doaj.art-684bae66b3424aed95a4874d8de81c94 |
| institution | Directory Open Access Journal |
| issn | 2304-0238 2616-7352 |
| language | English |
| last_indexed | 2024-04-24T23:54:00Z |
| publishDate | 2022-11-01 |
| publisher | State Institution «Institute of Nephrology NAMS of Ukraine" |
| record_format | Article |
| series | Український Журнал Нефрології та Діалізу |
| spelling | doaj.art-684bae66b3424aed95a4874d8de81c942024-03-14T16:55:04ZengState Institution «Institute of Nephrology NAMS of Ukraine"Український Журнал Нефрології та Діалізу2304-02382616-73522022-11-014(76)10.31450/ukrjnd.4(76).2022.09The potential mechanisms of cardiovascular calcification in patients with chronic kidney diseaseO. Susla0O. Bushtynska1I. Yakubyshyna2L. Logoyda3K. Symko4I. Mysula5I. Horbachevsky Ternopil National Medical UniversityI. Horbachevsky Ternopil National Medical UniversityI. Horbachevsky Ternopil National Medical UniversityI. Horbachevsky Ternopil National Medical UniversityI. Horbachevsky Ternopil National Medical UniversityI. Horbachevsky Ternopil National Medical University Based on current literature data, the important potential role of calciprotein particles, matrix vesicles, and extracellular matrix degradation in cardiovascular calcification mechanisms in chronic kidney disease (CKD) can be confirmed. The involvement of advanced glycation end products, insulin resistance, microRNAs, iron metabolism disorders, fluid overload, and hemodialysis treatment in these processes is discussed. It was concluded that the above potential mechanisms of ectopic calcification, which are being actively explored, are directly or indirectly related to endothelial damage/dysfunction and metabolic disturbances in the nitric oxide system. It was concluded that further thorough scientific investigations and close collaboration between clinical and experimental nephrologists are useful to optimize programs for the early detection of cardiovascular calcification, develop new effective therapeutic strategies, and improve the prognosis of CKD patients. https://ukrjnd.com.ua/index.php/journal/article/view/673chronic kidney disease, cardiovascular calcification, calciprotein particles, matrix vesicles, hemodialysis, endothelial dysfunction. |
| spellingShingle | O. Susla O. Bushtynska I. Yakubyshyna L. Logoyda K. Symko I. Mysula The potential mechanisms of cardiovascular calcification in patients with chronic kidney disease Український Журнал Нефрології та Діалізу chronic kidney disease, cardiovascular calcification, calciprotein particles, matrix vesicles, hemodialysis, endothelial dysfunction. |
| title | The potential mechanisms of cardiovascular calcification in patients with chronic kidney disease |
| title_full | The potential mechanisms of cardiovascular calcification in patients with chronic kidney disease |
| title_fullStr | The potential mechanisms of cardiovascular calcification in patients with chronic kidney disease |
| title_full_unstemmed | The potential mechanisms of cardiovascular calcification in patients with chronic kidney disease |
| title_short | The potential mechanisms of cardiovascular calcification in patients with chronic kidney disease |
| title_sort | potential mechanisms of cardiovascular calcification in patients with chronic kidney disease |
| topic | chronic kidney disease, cardiovascular calcification, calciprotein particles, matrix vesicles, hemodialysis, endothelial dysfunction. |
| url | https://ukrjnd.com.ua/index.php/journal/article/view/673 |
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