Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 cases
Background: Anal canal condyloma acuminatum (CA) is a refractory disease with a high recurrence rate caused by human papillomavirus (HPV). Multiple clinical trials demonstrate that anti-HPV biological dressing is safe and effective in treating HPV infection, which has been used in treating high-risk...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2022;volume=67;issue=2;spage=204;epage=204;aulast=Hu |
| _version_ | 1818503567598682112 |
|---|---|
| author | Yanyan Hu Meihua Li Jing Liu Qian Huang Jinbo Chen Liuqing Chen Dongsheng Li |
| author_facet | Yanyan Hu Meihua Li Jing Liu Qian Huang Jinbo Chen Liuqing Chen Dongsheng Li |
| author_sort | Yanyan Hu |
| collection | DOAJ |
| description | Background: Anal canal condyloma acuminatum (CA) is a refractory disease with a high recurrence rate caused by human papillomavirus (HPV). Multiple clinical trials demonstrate that anti-HPV biological dressing is safe and effective in treating HPV infection, which has been used in treating high-risk HPV-positive and cervical intraepithelial neoplasia I (CIN I) patients. Yet, there is still a lack of clinical data for the treatment of anal canal CA. Aims and Objectives: To evaluate the clinical efficacy and application value of anti-HPV biological dressing in anal canal CA. Materials and Methods: Taken currently recommended treatment 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) as a positive control, 128 patients were included with 64 in each group, and a prospective, randomized, positive controlled, non-inferiority clinical trial was conducted. After removing visible skin lesions with conventional microwave, the treatment group was given anti-HPV biological dressing, while the control group received the conventional ALA-PDT treatment. Patients were followed up on the 1st, 12th and 24th weeks after the treatment. The cure rate, recurrence rate, HPV-negative conversion rate, and adverse events were recorded. Results: In the 1st, 12th and 24th weeks after treatment, the cure rate, recurrence rate and HPV-negative conversion rate of the treatment group and the control group showed no statistically significant difference. In the treatment group, 56 patients developed transient mild itching and all were relieved spontaneously, while in the control group, most of the patients experienced obvious pain and some patients needed symptomatic treatment. No severe systemic adverse events were observed. Conclusion: Compared with ALA-PDT, topical application of anti-HPV biological dressing has comparable promising outcomes in the treatment of anal canal CA, with fewer side effects and simpler operation making it suitable for clinical applications. |
| first_indexed | 2024-12-10T21:25:41Z |
| format | Article |
| id | doaj.art-684f00c2e2ef43d58de2c86b462edc7f |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-10T21:25:41Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-684f00c2e2ef43d58de2c86b462edc7f2022-12-22T01:33:00ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112022-01-0167220420410.4103/ijd.ijd_930_21Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 casesYanyan HuMeihua LiJing LiuQian HuangJinbo ChenLiuqing ChenDongsheng LiBackground: Anal canal condyloma acuminatum (CA) is a refractory disease with a high recurrence rate caused by human papillomavirus (HPV). Multiple clinical trials demonstrate that anti-HPV biological dressing is safe and effective in treating HPV infection, which has been used in treating high-risk HPV-positive and cervical intraepithelial neoplasia I (CIN I) patients. Yet, there is still a lack of clinical data for the treatment of anal canal CA. Aims and Objectives: To evaluate the clinical efficacy and application value of anti-HPV biological dressing in anal canal CA. Materials and Methods: Taken currently recommended treatment 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) as a positive control, 128 patients were included with 64 in each group, and a prospective, randomized, positive controlled, non-inferiority clinical trial was conducted. After removing visible skin lesions with conventional microwave, the treatment group was given anti-HPV biological dressing, while the control group received the conventional ALA-PDT treatment. Patients were followed up on the 1st, 12th and 24th weeks after the treatment. The cure rate, recurrence rate, HPV-negative conversion rate, and adverse events were recorded. Results: In the 1st, 12th and 24th weeks after treatment, the cure rate, recurrence rate and HPV-negative conversion rate of the treatment group and the control group showed no statistically significant difference. In the treatment group, 56 patients developed transient mild itching and all were relieved spontaneously, while in the control group, most of the patients experienced obvious pain and some patients needed symptomatic treatment. No severe systemic adverse events were observed. Conclusion: Compared with ALA-PDT, topical application of anti-HPV biological dressing has comparable promising outcomes in the treatment of anal canal CA, with fewer side effects and simpler operation making it suitable for clinical applications.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2022;volume=67;issue=2;spage=204;epage=204;aulast=Hu5-aminolevulinic acid-based photodynamic therapyanal canal condyloma acuminatumanti-hpv biological dressing |
| spellingShingle | Yanyan Hu Meihua Li Jing Liu Qian Huang Jinbo Chen Liuqing Chen Dongsheng Li Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 cases Indian Journal of Dermatology 5-aminolevulinic acid-based photodynamic therapy anal canal condyloma acuminatum anti-hpv biological dressing |
| title | Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 cases |
| title_full | Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 cases |
| title_fullStr | Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 cases |
| title_full_unstemmed | Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 cases |
| title_short | Anal canal condyloma acuminatum treated with anti-HPV biological dressing: Clinical analysis of 64 cases |
| title_sort | anal canal condyloma acuminatum treated with anti hpv biological dressing clinical analysis of 64 cases |
| topic | 5-aminolevulinic acid-based photodynamic therapy anal canal condyloma acuminatum anti-hpv biological dressing |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2022;volume=67;issue=2;spage=204;epage=204;aulast=Hu |
| work_keys_str_mv | AT yanyanhu analcanalcondylomaacuminatumtreatedwithantihpvbiologicaldressingclinicalanalysisof64cases AT meihuali analcanalcondylomaacuminatumtreatedwithantihpvbiologicaldressingclinicalanalysisof64cases AT jingliu analcanalcondylomaacuminatumtreatedwithantihpvbiologicaldressingclinicalanalysisof64cases AT qianhuang analcanalcondylomaacuminatumtreatedwithantihpvbiologicaldressingclinicalanalysisof64cases AT jinbochen analcanalcondylomaacuminatumtreatedwithantihpvbiologicaldressingclinicalanalysisof64cases AT liuqingchen analcanalcondylomaacuminatumtreatedwithantihpvbiologicaldressingclinicalanalysisof64cases AT dongshengli analcanalcondylomaacuminatumtreatedwithantihpvbiologicaldressingclinicalanalysisof64cases |