Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index
Abstract Purpose We aimed to explore the relationship between bone mineral density (BMD), bone metabolism markers, and blood lipid-related indicators, body mass index (BMI) in elderly individuals. Methods A retrospective analysis was conducted on 710 patients. Patients’ gender, age, height, weight,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-024-07284-6 |
| _version_ | 1797276188907929600 |
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| author | Hao Han Ran Li Dongming Fu Hongyou Zhou Zihao Zhan Yi’ang Wu Bin Meng |
| author_facet | Hao Han Ran Li Dongming Fu Hongyou Zhou Zihao Zhan Yi’ang Wu Bin Meng |
| author_sort | Hao Han |
| collection | DOAJ |
| description | Abstract Purpose We aimed to explore the relationship between bone mineral density (BMD), bone metabolism markers, and blood lipid-related indicators, body mass index (BMI) in elderly individuals. Methods A retrospective analysis was conducted on 710 patients. Patients’ gender, age, height, weight, bone density values, T-scores, bone metabolism markers (including serum N-terminal propeptide of type I collagen (s-PINP), serum C-terminal telopeptide of type I collagen (s-CTX) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and lipid-related indicators (including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and Castelli index 1 (TC/HDL-C index) and Castelli index 2 (LDL-C/HDL-C index) were recorded. Correlations between variables were analyzed, and patients were grouped according to gender and T-score for intergroup comparisons. Results HDL-C negatively correlates with BMD and s-CTX. TG, Castelli index, and BMI positively correlate with BMD. BMI negatively correlates with s-PINP. 1,25(OH)2D3 negatively correlates with TC, LDL-C, and Castelli index. LDL-C positively correlates with BMD in males, and TC negatively correlates with s-PINP. In females, HDL-C negatively correlates with BMD, and s-CTX positively correlates with Castelli index. 1,25(OH)2D3 negatively correlates with TC, LDL-C, and Castelli index. TG and Castelli index were higher in normal bone mass group, while HDL-C is higher in the osteoporosis group. TG and BMI positively predicted bone mass density, while HDL-C negatively predicted bone mass density. Conclusions HDL-C may have a predictive role in osteoporosis, particularly in women. The likelihood of osteoporosis is lower in individuals with high BMI or hyperlipidemia. Some lipid metabolism markers can be used to predict osteoporosis, and further research is needed. |
| first_indexed | 2024-03-07T15:24:47Z |
| format | Article |
| id | doaj.art-68502e280acb4a4abf19ccaf0e347a86 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-03-07T15:24:47Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-68502e280acb4a4abf19ccaf0e347a862024-03-05T17:24:06ZengBMCBMC Musculoskeletal Disorders1471-24742024-02-0125111210.1186/s12891-024-07284-6Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass indexHao Han0Ran Li1Dongming Fu2Hongyou Zhou3Zihao Zhan4Yi’ang Wu5Bin Meng6Department of Orthopedics, The First Affiliated Hospital of Soochow UniversityDepartment of Orthopedics, The First Affiliated Hospital of Soochow UniversityDepartment of Orthopedics, The First Affiliated Hospital of Soochow UniversityDepartment of Orthopedics, The First Affiliated Hospital of Soochow UniversityDepartment of Orthopedics, The First Affiliated Hospital of Soochow UniversityDepartment of Orthopedics, The First Affiliated Hospital of Soochow UniversityDepartment of Orthopedics, The First Affiliated Hospital of Soochow UniversityAbstract Purpose We aimed to explore the relationship between bone mineral density (BMD), bone metabolism markers, and blood lipid-related indicators, body mass index (BMI) in elderly individuals. Methods A retrospective analysis was conducted on 710 patients. Patients’ gender, age, height, weight, bone density values, T-scores, bone metabolism markers (including serum N-terminal propeptide of type I collagen (s-PINP), serum C-terminal telopeptide of type I collagen (s-CTX) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and lipid-related indicators (including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and Castelli index 1 (TC/HDL-C index) and Castelli index 2 (LDL-C/HDL-C index) were recorded. Correlations between variables were analyzed, and patients were grouped according to gender and T-score for intergroup comparisons. Results HDL-C negatively correlates with BMD and s-CTX. TG, Castelli index, and BMI positively correlate with BMD. BMI negatively correlates with s-PINP. 1,25(OH)2D3 negatively correlates with TC, LDL-C, and Castelli index. LDL-C positively correlates with BMD in males, and TC negatively correlates with s-PINP. In females, HDL-C negatively correlates with BMD, and s-CTX positively correlates with Castelli index. 1,25(OH)2D3 negatively correlates with TC, LDL-C, and Castelli index. TG and Castelli index were higher in normal bone mass group, while HDL-C is higher in the osteoporosis group. TG and BMI positively predicted bone mass density, while HDL-C negatively predicted bone mass density. Conclusions HDL-C may have a predictive role in osteoporosis, particularly in women. The likelihood of osteoporosis is lower in individuals with high BMI or hyperlipidemia. Some lipid metabolism markers can be used to predict osteoporosis, and further research is needed.https://doi.org/10.1186/s12891-024-07284-6OsteoporosisBone mineral densityBone turnover markersLipid profileBody mass index |
| spellingShingle | Hao Han Ran Li Dongming Fu Hongyou Zhou Zihao Zhan Yi’ang Wu Bin Meng Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index BMC Musculoskeletal Disorders Osteoporosis Bone mineral density Bone turnover markers Lipid profile Body mass index |
| title | Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index |
| title_full | Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index |
| title_fullStr | Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index |
| title_full_unstemmed | Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index |
| title_short | Correlation between bone density, bone metabolism markers with lipid metabolism markers and body mass index |
| title_sort | correlation between bone density bone metabolism markers with lipid metabolism markers and body mass index |
| topic | Osteoporosis Bone mineral density Bone turnover markers Lipid profile Body mass index |
| url | https://doi.org/10.1186/s12891-024-07284-6 |
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