The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine
Yong-Kang Gui,1,2,* Xiao-Hui Zeng,1,2,* Rui Xiao,3 Wen-Feng Xi,1– 3 Dan Zhang,1– 3 Yang Liu,1,2 Si-Hui Zhu,1,2 Xin Da,1,2 De-Wen Shi,1,2 Xu-Dong Hu,1,2 Guang-Hong Xu1,2 1Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, Peo...
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Dove Medical Press
2023-12-01
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| author | Gui YK Zeng XH Xiao R Xi WF Zhang D Liu Y Zhu SH Da X Shi DW Hu XD Xu GH |
| author_facet | Gui YK Zeng XH Xiao R Xi WF Zhang D Liu Y Zhu SH Da X Shi DW Hu XD Xu GH |
| author_sort | Gui YK |
| collection | DOAJ |
| description | Yong-Kang Gui,1,2,* Xiao-Hui Zeng,1,2,* Rui Xiao,3 Wen-Feng Xi,1– 3 Dan Zhang,1– 3 Yang Liu,1,2 Si-Hui Zhu,1,2 Xin Da,1,2 De-Wen Shi,1,2 Xu-Dong Hu,1,2 Guang-Hong Xu1,2 1Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 2Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 3Department of Anesthesiology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236113, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guang-Hong Xu, 230032, Tel +86 13856949535, Fax +86 0551 62923704, Email xuguanghong2004@163.comPurpose: The application of sedation and analgesia in spinal anesthesia has many benefits, but the risk of respiratory depression (RD) caused by opioids cannot be ignored. We aimed to observe the effect of dezocine, a partial agonist of μ-receptor, on the median effective dose (ED50) of sufentanil-induced RD in patients undergoing spinal anesthesia combined with low-dose dexmedetomidine.Patients and Methods: Sixty-two patients were randomly assigned to dezocine group (DS) and control group (MS). After spinal anesthesia, mask oxygen (5 L/min) and dexmedetomidine (0.1 ug/kg) were given. Five minutes later, patients in the DS group received an Intravenous (IV) bolus of sufentanil and 0.05mg/kg dezocine, while patients in the MS group only received an IV bolus of sufentanil.Results: ED50 of DS group was 0.342 ug/kg, 95% confidence interval (CI) was (0.269, 0.623) ug/kg, and the ED50 of MS group was 0.291 ug/kg, 95% CI was (0.257, 0.346) ug/kg. There was no difference in the type and treatment measures of RD and hemodynamic changes between the two groups, and no serious adverse reactions occurred in either group.Conclusion: Dezocine can improve RD induced by sufentanil in patients with spinal anesthesia combined with low-dose dexmedetomidine, and increase the safety window of sufentanil use.Keywords: spinal anesthesia, respiratory depression, median effective dose, sufentanil, dezocine |
| first_indexed | 2024-03-09T02:05:42Z |
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| language | English |
| last_indexed | 2024-03-09T02:05:42Z |
| publishDate | 2023-12-01 |
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| series | Drug Design, Development and Therapy |
| spelling | doaj.art-68532e9a3aec460da23e83e835f467a42023-12-07T18:03:42ZengDove Medical PressDrug Design, Development and Therapy1177-88812023-12-01Volume 173687369688850The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose DexmedetomidineGui YKZeng XHXiao RXi WFZhang DLiu YZhu SHDa XShi DWHu XDXu GHYong-Kang Gui,1,2,* Xiao-Hui Zeng,1,2,* Rui Xiao,3 Wen-Feng Xi,1– 3 Dan Zhang,1– 3 Yang Liu,1,2 Si-Hui Zhu,1,2 Xin Da,1,2 De-Wen Shi,1,2 Xu-Dong Hu,1,2 Guang-Hong Xu1,2 1Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 2Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 3Department of Anesthesiology, Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, 236113, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guang-Hong Xu, 230032, Tel +86 13856949535, Fax +86 0551 62923704, Email xuguanghong2004@163.comPurpose: The application of sedation and analgesia in spinal anesthesia has many benefits, but the risk of respiratory depression (RD) caused by opioids cannot be ignored. We aimed to observe the effect of dezocine, a partial agonist of μ-receptor, on the median effective dose (ED50) of sufentanil-induced RD in patients undergoing spinal anesthesia combined with low-dose dexmedetomidine.Patients and Methods: Sixty-two patients were randomly assigned to dezocine group (DS) and control group (MS). After spinal anesthesia, mask oxygen (5 L/min) and dexmedetomidine (0.1 ug/kg) were given. Five minutes later, patients in the DS group received an Intravenous (IV) bolus of sufentanil and 0.05mg/kg dezocine, while patients in the MS group only received an IV bolus of sufentanil.Results: ED50 of DS group was 0.342 ug/kg, 95% confidence interval (CI) was (0.269, 0.623) ug/kg, and the ED50 of MS group was 0.291 ug/kg, 95% CI was (0.257, 0.346) ug/kg. There was no difference in the type and treatment measures of RD and hemodynamic changes between the two groups, and no serious adverse reactions occurred in either group.Conclusion: Dezocine can improve RD induced by sufentanil in patients with spinal anesthesia combined with low-dose dexmedetomidine, and increase the safety window of sufentanil use.Keywords: spinal anesthesia, respiratory depression, median effective dose, sufentanil, dezocinehttps://www.dovepress.com/the-effect-of-dezocine-on-the-median-effective-dose-of-sufentanil-indu-peer-reviewed-fulltext-article-DDDTspinal anesthesiarespiratory depressionmedian effective dosesufentanildezocine. |
| spellingShingle | Gui YK Zeng XH Xiao R Xi WF Zhang D Liu Y Zhu SH Da X Shi DW Hu XD Xu GH The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine Drug Design, Development and Therapy spinal anesthesia respiratory depression median effective dose sufentanil dezocine. |
| title | The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine |
| title_full | The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine |
| title_fullStr | The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine |
| title_full_unstemmed | The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine |
| title_short | The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine |
| title_sort | effect of dezocine on the median effective dose of sufentanil induced respiratory depression in patients undergoing spinal anesthesia combined with low dose dexmedetomidine |
| topic | spinal anesthesia respiratory depression median effective dose sufentanil dezocine. |
| url | https://www.dovepress.com/the-effect-of-dezocine-on-the-median-effective-dose-of-sufentanil-indu-peer-reviewed-fulltext-article-DDDT |
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