Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction
Background: Androgens have been shown to have diverse effects on the cardiovascular system. The aim of this study was to compare androgenic hormone levels in patients with different left ventricular ejection fractions (EF). Methods: The study population consisted of 515 consecutive men who were ref...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2010-09-01
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| Series: | Journal of Tehran University Heart Center |
| Subjects: | |
| Online Access: | https://jthc.tums.ac.ir/index.php/jthc/article/view/178 |
| _version_ | 1828781782026158080 |
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| author | Gholamreza Davoodi Alireza Amirzadegan Mohammad Ali Boroumand Maria Raissi Dehkordi Ali Kazemi Saeid Ahmad Yamini Sharif Mehrnaz Rezvanfard Maryam Sotoudeh Anvari |
| author_facet | Gholamreza Davoodi Alireza Amirzadegan Mohammad Ali Boroumand Maria Raissi Dehkordi Ali Kazemi Saeid Ahmad Yamini Sharif Mehrnaz Rezvanfard Maryam Sotoudeh Anvari |
| author_sort | Gholamreza Davoodi |
| collection | DOAJ |
| description | Background: Androgens have been shown to have diverse effects on the cardiovascular system. The aim of this study was to compare androgenic hormone levels in patients with different left ventricular ejection fractions (EF).
Methods: The study population consisted of 515 consecutive men who were referred for angiographic studies and whose results of echocardiography and coronary angiography were available. The patients were classified into four groups: EF < 35%, EF = 35-45%, EF = 45-54%, and EF ≥ 55% to evaluate the trends of baseline characteristics and serum androgens, including free testosterone (fT), total testosterone (tT), and dehydroepiandrosterone sulfate (DHEAS). To better elucidate the difference in the patients with severe heart failure, the patients were divided into two groups according to their EF level, and comparisons were repeated between those with EF < 35% and the ones with EF ≥ 35%.
Results: There were statistically significant trends in some characteristics in the patients with different levels of EF. The subjects with higher EF levels were less likely to have diabetes (p value < 0.001), coronary artery lesion (p value < 0.001), or high levels of C-reactive protein (CRP) (p value < 0.001). As regards the patients with severe heart failure, our regression analysis revealed that the fT level was significantly lower in those with EF < 35% than in the ones with EF ≥ 35% (5.82 ± 2.73 pg/mL vs. 6.88 ± 3.34 pg/mL, p value < 0.05).
Conclusion: A significant association was found between the level of fT and EF < 35%. There is a need for further controlled prospective studies to delineate any possible causal relationship accurately. |
| first_indexed | 2024-12-11T17:39:27Z |
| format | Article |
| id | doaj.art-685355ff0cc04bdda86e643598f7c1cf |
| institution | Directory Open Access Journal |
| issn | 1735-8620 2008-2371 |
| language | English |
| last_indexed | 2024-12-11T17:39:27Z |
| publishDate | 2010-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Tehran University Heart Center |
| spelling | doaj.art-685355ff0cc04bdda86e643598f7c1cf2022-12-22T00:56:35ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202008-23712010-09-0153176Association between Androgenic Hormone Levels and Left Ventricular Ejection FractionGholamreza Davoodi0Alireza Amirzadegan1Mohammad Ali Boroumand2Maria Raissi Dehkordi3Ali Kazemi Saeid4Ahmad Yamini Sharif5Mehrnaz Rezvanfard6Maryam Sotoudeh Anvari7Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Background: Androgens have been shown to have diverse effects on the cardiovascular system. The aim of this study was to compare androgenic hormone levels in patients with different left ventricular ejection fractions (EF). Methods: The study population consisted of 515 consecutive men who were referred for angiographic studies and whose results of echocardiography and coronary angiography were available. The patients were classified into four groups: EF < 35%, EF = 35-45%, EF = 45-54%, and EF ≥ 55% to evaluate the trends of baseline characteristics and serum androgens, including free testosterone (fT), total testosterone (tT), and dehydroepiandrosterone sulfate (DHEAS). To better elucidate the difference in the patients with severe heart failure, the patients were divided into two groups according to their EF level, and comparisons were repeated between those with EF < 35% and the ones with EF ≥ 35%. Results: There were statistically significant trends in some characteristics in the patients with different levels of EF. The subjects with higher EF levels were less likely to have diabetes (p value < 0.001), coronary artery lesion (p value < 0.001), or high levels of C-reactive protein (CRP) (p value < 0.001). As regards the patients with severe heart failure, our regression analysis revealed that the fT level was significantly lower in those with EF < 35% than in the ones with EF ≥ 35% (5.82 ± 2.73 pg/mL vs. 6.88 ± 3.34 pg/mL, p value < 0.05). Conclusion: A significant association was found between the level of fT and EF < 35%. There is a need for further controlled prospective studies to delineate any possible causal relationship accurately.https://jthc.tums.ac.ir/index.php/jthc/article/view/178TestosteroneAndrogensHeart failureVentricular functionleft |
| spellingShingle | Gholamreza Davoodi Alireza Amirzadegan Mohammad Ali Boroumand Maria Raissi Dehkordi Ali Kazemi Saeid Ahmad Yamini Sharif Mehrnaz Rezvanfard Maryam Sotoudeh Anvari Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction Journal of Tehran University Heart Center Testosterone Androgens Heart failure Ventricular function left |
| title | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_full | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_fullStr | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_full_unstemmed | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_short | Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction |
| title_sort | association between androgenic hormone levels and left ventricular ejection fraction |
| topic | Testosterone Androgens Heart failure Ventricular function left |
| url | https://jthc.tums.ac.ir/index.php/jthc/article/view/178 |
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