A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer's Disease in a Chinese Han Family: A Case Report

A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer's Disease in a Chinese Han Family: A Case Report

The pathogenesis of Alzheimer's disease is complex, and early-onset Alzheimer's disease (EOAD) is mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), and amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with...

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Bibliographic Details
Main Authors:	Ke Wan, Zhen-Juan Ma, Xia Zhou, Yi-Mei Zhang, Xian-Feng Yu, Meng-Zhe You, Chao-Juan Huang, Wei Zhang, Zhong-Wu Sun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Aging Neuroscience
Subjects:	early-onset Alzheimer's disease PSEN2 magnetic resonance imaging transmembrane domain 7 novel p.Phe369Ser mutation
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.710075/full

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