Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus
Psoriasis (PsO) is a chronic, immune-mediated, inflammatory skin disease associated in most cases with pruritus. Chemokines seem to play a significant role in PsO pathogenesis. The aim of the study was to analyse serum concentrations of CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL17/TARC,...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13330 |
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| author | Dorota Purzycka-Bohdan Bogusław Nedoszytko Monika Zabłotna Jolanta Gleń Aneta Szczerkowska-Dobosz Roman J. Nowicki |
| author_facet | Dorota Purzycka-Bohdan Bogusław Nedoszytko Monika Zabłotna Jolanta Gleń Aneta Szczerkowska-Dobosz Roman J. Nowicki |
| author_sort | Dorota Purzycka-Bohdan |
| collection | DOAJ |
| description | Psoriasis (PsO) is a chronic, immune-mediated, inflammatory skin disease associated in most cases with pruritus. Chemokines seem to play a significant role in PsO pathogenesis. The aim of the study was to analyse serum concentrations of CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL17/TARC, CCL18/PARC, CCL22/MDC and CXCL8/IL-8, and their correlation with PsO severity and pruritus intensity. The study included 60 PsO patients and 40 healthy volunteers. Serum concentrations of six (CCL2/MCP-1, CCL3/MIP-1α, CCL5/RANTES, CCL17/TARC, CCL18/PARC and CCL22/MDC) out of eight analysed chemokines were significantly elevated in PsO patients; however, they did not correlate with disease severity. The serum level of CCL5/RANTES was significantly higher in patients with the psoriasis area and severity index (PASI) ≥ 15 (<i>p</i> = 0.01). The serum concentration of CCL17/TARC correlated positively with pruritus assessed using the visual analogue scale (VAS) (R = 0.47; <i>p</i> = 0.05). The study indicated CCL17/TARC as a potential biomarker of pruritus intensity in PsO patients. Chemokines appear to be involved in the development of PsO systemic inflammation. Further detailed studies on the interactions between chemokines, proinflammatory cytokines and immune system cells in PsO are required to search for new targeted therapies. |
| first_indexed | 2024-03-09T19:00:36Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:00:36Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6855673234f14cb18da54579ace30e222023-11-24T05:06:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211333010.3390/ijms232113330Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and PruritusDorota Purzycka-Bohdan0Bogusław Nedoszytko1Monika Zabłotna2Jolanta Gleń3Aneta Szczerkowska-Dobosz4Roman J. Nowicki5Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, PolandDepartment of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-214 Gdansk, PolandPsoriasis (PsO) is a chronic, immune-mediated, inflammatory skin disease associated in most cases with pruritus. Chemokines seem to play a significant role in PsO pathogenesis. The aim of the study was to analyse serum concentrations of CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL17/TARC, CCL18/PARC, CCL22/MDC and CXCL8/IL-8, and their correlation with PsO severity and pruritus intensity. The study included 60 PsO patients and 40 healthy volunteers. Serum concentrations of six (CCL2/MCP-1, CCL3/MIP-1α, CCL5/RANTES, CCL17/TARC, CCL18/PARC and CCL22/MDC) out of eight analysed chemokines were significantly elevated in PsO patients; however, they did not correlate with disease severity. The serum level of CCL5/RANTES was significantly higher in patients with the psoriasis area and severity index (PASI) ≥ 15 (<i>p</i> = 0.01). The serum concentration of CCL17/TARC correlated positively with pruritus assessed using the visual analogue scale (VAS) (R = 0.47; <i>p</i> = 0.05). The study indicated CCL17/TARC as a potential biomarker of pruritus intensity in PsO patients. Chemokines appear to be involved in the development of PsO systemic inflammation. Further detailed studies on the interactions between chemokines, proinflammatory cytokines and immune system cells in PsO are required to search for new targeted therapies.https://www.mdpi.com/1422-0067/23/21/13330chemokinespsoriasisdisease severitypruritus |
| spellingShingle | Dorota Purzycka-Bohdan Bogusław Nedoszytko Monika Zabłotna Jolanta Gleń Aneta Szczerkowska-Dobosz Roman J. Nowicki Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus International Journal of Molecular Sciences chemokines psoriasis disease severity pruritus |
| title | Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus |
| title_full | Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus |
| title_fullStr | Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus |
| title_full_unstemmed | Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus |
| title_short | Chemokine Profile in Psoriasis Patients in Correlation with Disease Severity and Pruritus |
| title_sort | chemokine profile in psoriasis patients in correlation with disease severity and pruritus |
| topic | chemokines psoriasis disease severity pruritus |
| url | https://www.mdpi.com/1422-0067/23/21/13330 |
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