Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging System
IntroductionRecently, the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system was updated for its 8th edition. F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a useful imaging tool to diagnose and predict pro...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.861867/full |
| _version_ | 1811229144496734208 |
|---|---|
| author | Hyunjong Lee Kyung Soo Lee Yang Won Min Hong Kwan Kim Jae Ill Zo Young Mog Shim Joon Young Choi |
| author_facet | Hyunjong Lee Kyung Soo Lee Yang Won Min Hong Kwan Kim Jae Ill Zo Young Mog Shim Joon Young Choi |
| author_sort | Hyunjong Lee |
| collection | DOAJ |
| description | IntroductionRecently, the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system was updated for its 8th edition. F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a useful imaging tool to diagnose and predict prognoses for esophageal cancer. However, there was no previous study to explore the role of FDG PET/CT in the staging system based on the 8th edition. The prognostic value of FDG PET/CT was investigated in patients with esophageal squamous cell carcinoma (SqCC) considering the new 8th AJCC/UICC staging system.MethodsSubjects were 721 patients with esophageal SqCC undergoing pretherapeutic FDG PET/CT. Clinico-pathological variables and the maximum standardized uptake value (SUVmax) of the primary tumor were included in survival analysis. Subgroup analysis was performed to compare hazard ratios according to pathological stage and SUVmax. A new staging classification including FDG uptake was proposed.ResultsIn multivariate survival analysis, pathological stage and SUVmax of the primary tumor were selected as independent prognostic factors for overall survival in both the 7th and 8th editions. The proposed new staging system showed better discrimination for overall survival between stage I and II than did the conventional staging system (hazard ratios: 2.250 vs. 1.341).ConclusionsThe FDG uptake of the primary tumor was found to be an independent prognostic factor along with pathological stage based on both 7th and 8th AJCC/UICC staging systems in patients with esophageal SqCC. The suggested new staging system including SUVmax was better for predicting prognoses than the conventional staging system. |
| first_indexed | 2024-04-12T10:09:58Z |
| format | Article |
| id | doaj.art-6855ad0a65564feab5ef8b26cc59757e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T10:09:58Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6855ad0a65564feab5ef8b26cc59757e2022-12-22T03:37:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.861867861867Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging SystemHyunjong Lee0Kyung Soo Lee1Yang Won Min2Hong Kwan Kim3Jae Ill Zo4Young Mog Shim5Joon Young Choi6Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Radiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDepartment of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaIntroductionRecently, the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC) staging system was updated for its 8th edition. F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a useful imaging tool to diagnose and predict prognoses for esophageal cancer. However, there was no previous study to explore the role of FDG PET/CT in the staging system based on the 8th edition. The prognostic value of FDG PET/CT was investigated in patients with esophageal squamous cell carcinoma (SqCC) considering the new 8th AJCC/UICC staging system.MethodsSubjects were 721 patients with esophageal SqCC undergoing pretherapeutic FDG PET/CT. Clinico-pathological variables and the maximum standardized uptake value (SUVmax) of the primary tumor were included in survival analysis. Subgroup analysis was performed to compare hazard ratios according to pathological stage and SUVmax. A new staging classification including FDG uptake was proposed.ResultsIn multivariate survival analysis, pathological stage and SUVmax of the primary tumor were selected as independent prognostic factors for overall survival in both the 7th and 8th editions. The proposed new staging system showed better discrimination for overall survival between stage I and II than did the conventional staging system (hazard ratios: 2.250 vs. 1.341).ConclusionsThe FDG uptake of the primary tumor was found to be an independent prognostic factor along with pathological stage based on both 7th and 8th AJCC/UICC staging systems in patients with esophageal SqCC. The suggested new staging system including SUVmax was better for predicting prognoses than the conventional staging system.https://www.frontiersin.org/articles/10.3389/fonc.2022.861867/fullesophageal cancersquamous cell carcinomaFDG PET/CTprognosis8th AJCC staging system |
| spellingShingle | Hyunjong Lee Kyung Soo Lee Yang Won Min Hong Kwan Kim Jae Ill Zo Young Mog Shim Joon Young Choi Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging System Frontiers in Oncology esophageal cancer squamous cell carcinoma FDG PET/CT prognosis 8th AJCC staging system |
| title | Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging System |
| title_full | Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging System |
| title_fullStr | Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging System |
| title_full_unstemmed | Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging System |
| title_short | Prognostic Significance of FDG PET/CT in Esophageal Squamous Cell Carcinoma in the Era of the 8th AJCC/UICC Staging System |
| title_sort | prognostic significance of fdg pet ct in esophageal squamous cell carcinoma in the era of the 8th ajcc uicc staging system |
| topic | esophageal cancer squamous cell carcinoma FDG PET/CT prognosis 8th AJCC staging system |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.861867/full |
| work_keys_str_mv | AT hyunjonglee prognosticsignificanceoffdgpetctinesophagealsquamouscellcarcinomaintheeraofthe8thajccuiccstagingsystem AT kyungsoolee prognosticsignificanceoffdgpetctinesophagealsquamouscellcarcinomaintheeraofthe8thajccuiccstagingsystem AT yangwonmin prognosticsignificanceoffdgpetctinesophagealsquamouscellcarcinomaintheeraofthe8thajccuiccstagingsystem AT hongkwankim prognosticsignificanceoffdgpetctinesophagealsquamouscellcarcinomaintheeraofthe8thajccuiccstagingsystem AT jaeillzo prognosticsignificanceoffdgpetctinesophagealsquamouscellcarcinomaintheeraofthe8thajccuiccstagingsystem AT youngmogshim prognosticsignificanceoffdgpetctinesophagealsquamouscellcarcinomaintheeraofthe8thajccuiccstagingsystem AT joonyoungchoi prognosticsignificanceoffdgpetctinesophagealsquamouscellcarcinomaintheeraofthe8thajccuiccstagingsystem |