Rheumatoid factor IgM autoantibodies control IgG homeostasis

Rheumatoid factor IgM autoantibodies control IgG homeostasis

Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation due to autoantibodies targeting multiple self-proteins. Most patients with poor prognosis show elevated titers of IgM antibodies specifically binding to IgG. Such autoreactive antibodies are referred to as rheumatoid f...

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Bibliographic Details
Main Authors: Antonella Nicolò, Timm Amendt, Omar El Ayoubi, Marc Young, Stephanie Finzel, Makbule Senel, Reinhard E. Voll, Hassan Jumaa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
autoantibodies
rheumatoid factor
affinity
homeostasis
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1016263/full

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