Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients
Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory <i>TGF-β1</i>- and <i>IL-10</i>-specific single-nucleotide pol...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/12/6/930 |
| _version_ | 1797529704127791104 |
|---|---|
| author | Min-Yu Tu Kuei-Yang Han Ying-Wei Lan Ku-Yi Chang Cheng-Wei Lai Theresa Staniczek Chung-Yu Lai Kowit-Yu Chong Chuan-Mu Chen |
| author_facet | Min-Yu Tu Kuei-Yang Han Ying-Wei Lan Ku-Yi Chang Cheng-Wei Lai Theresa Staniczek Chung-Yu Lai Kowit-Yu Chong Chuan-Mu Chen |
| author_sort | Min-Yu Tu |
| collection | DOAJ |
| description | Osteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory <i>TGF-β1</i>- and <i>IL-10</i>-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three <i>TGF-β1</i> SNPs (−509C/T, +869 T/C and +29T/C), one <i>IL-10</i> SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with <i>TGF-β1</i> SNP (−509 C/C) and <i>IL-10</i> SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of <i>TGF-β1</i> SNP (−509 T/T) and <i>IL-10</i> SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The <i>TGF-β1</i> SNP (−509 C/T) genotype in all subjects and <i>TGF-β1</i> SNP (−509 T/T) and <i>IL-10</i> SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory <i>TGF-β1</i> and <i>IL-10</i> genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of <i>TGF-β1</i> (−509) and <i>IL-10</i> (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women. |
| first_indexed | 2024-03-10T10:17:35Z |
| format | Article |
| id | doaj.art-685baae6e9ff4d47a01b2c9a29caf089 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T10:17:35Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-685baae6e9ff4d47a01b2c9a29caf0892023-11-22T00:41:44ZengMDPI AGGenes2073-44252021-06-0112693010.3390/genes12060930Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic PatientsMin-Yu Tu0Kuei-Yang Han1Ying-Wei Lan2Ku-Yi Chang3Cheng-Wei Lai4Theresa Staniczek5Chung-Yu Lai6Kowit-Yu Chong7Chuan-Mu Chen8Department of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanDepartment of Family Medicine, Jen-Ai Hospital, Dali Branch, Taichung 402, TaiwanDepartment of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanDepartment of Orthopedic Surgery, Jen-Ai Hospital, Dali Branch, Taichung 402, TaiwanDepartment of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanDepartment of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanGraduate Institute of Aerospace and Undersea Medicine, National Defense Medical Center, Taipei 114, TaiwanDepartment of Medical Biotechnology and Laboratory Science and Graduate Institute of Biomedical Sciences, Division of Biotechnology, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanDepartment of Life Sciences and Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 402, TaiwanOsteoporosis is a rising health threat in the increasingly aging world population. It is a common skeletal disease strongly linked to genetic predisposition. We aim to identify the effects of the anti-inflammatory <i>TGF-β1</i>- and <i>IL-10</i>-specific single-nucleotide polymorphism (SNP) combination on the risk for osteoporosis. We investigated and analyzed the relationships between three <i>TGF-β1</i> SNPs (−509C/T, +869 T/C and +29T/C), one <i>IL-10</i> SNP (+1927A/C) and the level of bone mineral density (BMD), as well as the risk of osteoporosis in Taiwanese osteoporotic patients. A total of 217 subjects were recruited, including 88 osteoporotic patients and 129 healthy controls, for SNPs, BMD and clinical characteristics statistical analyses. Females with <i>TGF-β1</i> SNP (−509 C/C) and <i>IL-10</i> SNP (+1927 C/C) genotypes showed a great benefit for femoral neck T-scores. However, the combination of <i>TGF-β1</i> SNP (−509 T/T) and <i>IL-10</i> SNP (+1927 A/A) genotypes in all subjects showed a significant decrease in total hip BMD T-scores. The <i>TGF-β1</i> SNP (−509 C/T) genotype in all subjects and <i>TGF-β1</i> SNP (−509 T/T) and <i>IL-10</i> SNP (+1927 A/C) genotypes in males showed positive effects on body height. The combination of the many SNPs in the anti-inflammatory <i>TGF-β1</i> and <i>IL-10</i> genes may be cooperatively involved in the development of osteoporosis. Our data suggested that the specific SNP combination of <i>TGF-β1</i> (−509) and <i>IL-10</i> (+1927) may act as a predictive factor for postmenopausal osteoporosis in Taiwanese women.https://www.mdpi.com/2073-4425/12/6/930osteoporosissingle-nucleotide polymorphism (SNP)anti-inflammatory cytokinetransforming growth factor-β1 (TGF-β1)interleukin-10 (IL-10)bone mineral density (BMD) |
| spellingShingle | Min-Yu Tu Kuei-Yang Han Ying-Wei Lan Ku-Yi Chang Cheng-Wei Lai Theresa Staniczek Chung-Yu Lai Kowit-Yu Chong Chuan-Mu Chen Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients Genes osteoporosis single-nucleotide polymorphism (SNP) anti-inflammatory cytokine transforming growth factor-β1 (TGF-β1) interleukin-10 (IL-10) bone mineral density (BMD) |
| title | Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients |
| title_full | Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients |
| title_fullStr | Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients |
| title_full_unstemmed | Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients |
| title_short | Association of <i>TGF-β1</i> and <i>IL-10</i> Gene Polymorphisms with Osteoporosis in a Study of Taiwanese Osteoporotic Patients |
| title_sort | association of i tgf β1 i and i il 10 i gene polymorphisms with osteoporosis in a study of taiwanese osteoporotic patients |
| topic | osteoporosis single-nucleotide polymorphism (SNP) anti-inflammatory cytokine transforming growth factor-β1 (TGF-β1) interleukin-10 (IL-10) bone mineral density (BMD) |
| url | https://www.mdpi.com/2073-4425/12/6/930 |
| work_keys_str_mv | AT minyutu associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT kueiyanghan associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT yingweilan associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT kuyichang associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT chengweilai associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT theresastaniczek associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT chungyulai associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT kowityuchong associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients AT chuanmuchen associationofitgfb1iandiil10igenepolymorphismswithosteoporosisinastudyoftaiwaneseosteoporoticpatients |