A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer
Background: Giant tumors of the abdominal cavity, as a rule, occur in elderly patients with characteristic features and represent a serious problem in terms of choosing a radical method of therapy. Of particular difficulty are cases of giant serous endometrial cancer, requiring a differential diagno...
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| Format: | Article |
| Language: | English |
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Eco-vector
2021-12-01
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| Series: | Клиническая практика |
| Subjects: | |
| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/90662/pdf |
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| author | Aleksander I. Berishvili Yuri V. Ivanov Dmitry P. Lebedev Fedor G. Zabozlaev Edward V. Kravchenko Tatiana V. Klypa Anna G. Kedrova |
| author_facet | Aleksander I. Berishvili Yuri V. Ivanov Dmitry P. Lebedev Fedor G. Zabozlaev Edward V. Kravchenko Tatiana V. Klypa Anna G. Kedrova |
| author_sort | Aleksander I. Berishvili |
| collection | DOAJ |
| description | Background: Giant tumors of the abdominal cavity, as a rule, occur in elderly patients with characteristic features and represent a serious problem in terms of choosing a radical method of therapy. Of particular difficulty are cases of giant serous endometrial cancer, requiring a differential diagnosis with ovarian cancer.
Clinical case description: A clinical case of giant serous endometrial cancer mimicking ovarian cancer in a 55-year-old woman is presented. The patient came to the oncology department with complaints of abdominal enlargement, difficulty breathing and bloody discharge from the genital tract. The examination revealed the following: a giant formation (4065 cm), occupying the entire pelvic and the entire abdominal cavities, ascites, lesions of the retroperitoneal lymph nodes, and the greater omentum, an umbilical hernia. A chest CT showed multiple contrast-accumulating circular shadows of 313 mm (metastases). By the decision of the council, after the preliminary chemoembolization of both the uterine and ovarian arteries, a supravaginal amputation of the uterus with appendages was performed, along with the resection of the greater omentum, removal of the umbilical hernia with positioning a plastic mesh implant and excision of an excess skin flap. The histological examination of the intraoperative material made it possible to verify the diagnosis of a serous endometrial carcinoma with subtotal tumor necrosis, the myometrium invasion of more than a half of its thickness, with the egress to the perimetrium, metastatic lesions of both ovaries, the greater omentum, anterior abdominal wall. Stage T3b (FIGO IIIB). In the postoperative period, 6 courses of Paclitaxel / Carboplatin (AUC4-5) chemotherapy were carried out with a pronounced clinical effect. The patient was discharged in a satisfactory condition. The control PET-CT scan after the 6th chemotherapy course showed no pathology in the thoracic cavity, and no process progress in the abdominal cavity. Currently, the remission of the disease is 9 months.
Conclusion: An algorithm for the diagnostic measures aimed at making the correct diagnosis is presented, and the tactics of treating a patient with giant serous endometrial cancer is described. |
| first_indexed | 2024-03-12T18:13:17Z |
| format | Article |
| id | doaj.art-685c563578274094b74aed6a7e122d72 |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T18:13:17Z |
| publishDate | 2021-12-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-685c563578274094b74aed6a7e122d722023-08-02T09:13:15ZengEco-vectorКлиническая практика2220-30952618-86272021-12-01124808510.17816/clinpract9066278300A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancerAleksander I. Berishvili0Yuri V. Ivanov1https://orcid.org/0000-0001-6209-4194Dmitry P. Lebedev2https://orcid.org/0000-0003-1551-3127Fedor G. Zabozlaev3https://orcid.org/0000-0002-7445-8319Edward V. Kravchenko4Tatiana V. Klypa5https://orcid.org/0000-0002-2732-967XAnna G. Kedrova6https://orcid.org/0000-0003-1031-9376Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical TechnologiesFederal Scientific and Clinical Center for Specialized Medical Assistance and Medical TechnologiesFederal Scientific and Clinical Center for Specialized Medical Assistance and Medical TechnologiesFederal Scientific and Clinical Center for Specialized Medical Assistance and Medical TechnologiesFederal Scientific and Clinical Center for Specialized Medical Assistance and Medical TechnologiesFederal Scientific and Clinical Center for Specialized Medical Assistance and Medical TechnologiesFederal Scientific and Clinical Center for Specialized Medical Assistance and Medical TechnologiesBackground: Giant tumors of the abdominal cavity, as a rule, occur in elderly patients with characteristic features and represent a serious problem in terms of choosing a radical method of therapy. Of particular difficulty are cases of giant serous endometrial cancer, requiring a differential diagnosis with ovarian cancer. Clinical case description: A clinical case of giant serous endometrial cancer mimicking ovarian cancer in a 55-year-old woman is presented. The patient came to the oncology department with complaints of abdominal enlargement, difficulty breathing and bloody discharge from the genital tract. The examination revealed the following: a giant formation (4065 cm), occupying the entire pelvic and the entire abdominal cavities, ascites, lesions of the retroperitoneal lymph nodes, and the greater omentum, an umbilical hernia. A chest CT showed multiple contrast-accumulating circular shadows of 313 mm (metastases). By the decision of the council, after the preliminary chemoembolization of both the uterine and ovarian arteries, a supravaginal amputation of the uterus with appendages was performed, along with the resection of the greater omentum, removal of the umbilical hernia with positioning a plastic mesh implant and excision of an excess skin flap. The histological examination of the intraoperative material made it possible to verify the diagnosis of a serous endometrial carcinoma with subtotal tumor necrosis, the myometrium invasion of more than a half of its thickness, with the egress to the perimetrium, metastatic lesions of both ovaries, the greater omentum, anterior abdominal wall. Stage T3b (FIGO IIIB). In the postoperative period, 6 courses of Paclitaxel / Carboplatin (AUC4-5) chemotherapy were carried out with a pronounced clinical effect. The patient was discharged in a satisfactory condition. The control PET-CT scan after the 6th chemotherapy course showed no pathology in the thoracic cavity, and no process progress in the abdominal cavity. Currently, the remission of the disease is 9 months. Conclusion: An algorithm for the diagnostic measures aimed at making the correct diagnosis is presented, and the tactics of treating a patient with giant serous endometrial cancer is described.https://journals.eco-vector.com/clinpractice/article/viewFile/90662/pdfserous endometrial cancergiant tumorsurgerychemotherapy |
| spellingShingle | Aleksander I. Berishvili Yuri V. Ivanov Dmitry P. Lebedev Fedor G. Zabozlaev Edward V. Kravchenko Tatiana V. Klypa Anna G. Kedrova A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer Клиническая практика serous endometrial cancer giant tumor surgery chemotherapy |
| title | A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer |
| title_full | A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer |
| title_fullStr | A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer |
| title_full_unstemmed | A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer |
| title_short | A clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer |
| title_sort | clinical case of successful treatment of a giant serous endometrial carcinoma imitating ovarian cancer |
| topic | serous endometrial cancer giant tumor surgery chemotherapy |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/90662/pdf |
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