Nucleated red blood cells explain most of the association between DNA methylation and gestational age

CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.

Bibliographic Details
Main Authors: Kristine L. Haftorn, William R. P. Denault, Yunsung Lee, Christian M. Page, Julia Romanowska, Robert Lyle, Øyvind E. Næss, Dana Kristjansson, Per M. Magnus, Siri E. Håberg, Jon Bohlin, Astanand Jugessur
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04584-w
_version_ 1797863805944856576
author Kristine L. Haftorn
William R. P. Denault
Yunsung Lee
Christian M. Page
Julia Romanowska
Robert Lyle
Øyvind E. Næss
Dana Kristjansson
Per M. Magnus
Siri E. Håberg
Jon Bohlin
Astanand Jugessur
author_facet Kristine L. Haftorn
William R. P. Denault
Yunsung Lee
Christian M. Page
Julia Romanowska
Robert Lyle
Øyvind E. Næss
Dana Kristjansson
Per M. Magnus
Siri E. Håberg
Jon Bohlin
Astanand Jugessur
author_sort Kristine L. Haftorn
collection DOAJ
description CpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.
first_indexed 2024-04-09T22:42:38Z
format Article
id doaj.art-685ca7f611554c978bb43c19b97d8d3b
institution Directory Open Access Journal
issn 2399-3642
language English
last_indexed 2024-04-09T22:42:38Z
publishDate 2023-02-01
publisher Nature Portfolio
record_format Article
series Communications Biology
spelling doaj.art-685ca7f611554c978bb43c19b97d8d3b2023-03-22T12:04:47ZengNature PortfolioCommunications Biology2399-36422023-02-016111110.1038/s42003-023-04584-wNucleated red blood cells explain most of the association between DNA methylation and gestational ageKristine L. Haftorn0William R. P. Denault1Yunsung Lee2Christian M. Page3Julia Romanowska4Robert Lyle5Øyvind E. Næss6Dana Kristjansson7Per M. Magnus8Siri E. Håberg9Jon Bohlin10Astanand Jugessur11Centre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthInstitute of Health and Society, University of OsloCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCentre for Fertility and Health, Norwegian Institute of Public HealthCpG sites associated with gestational age are predominantly found in nucleated red blood cells, which point to an epigenetic signature of erythropoiesis as being partly responsible for this association.https://doi.org/10.1038/s42003-023-04584-w
spellingShingle Kristine L. Haftorn
William R. P. Denault
Yunsung Lee
Christian M. Page
Julia Romanowska
Robert Lyle
Øyvind E. Næss
Dana Kristjansson
Per M. Magnus
Siri E. Håberg
Jon Bohlin
Astanand Jugessur
Nucleated red blood cells explain most of the association between DNA methylation and gestational age
Communications Biology
title Nucleated red blood cells explain most of the association between DNA methylation and gestational age
title_full Nucleated red blood cells explain most of the association between DNA methylation and gestational age
title_fullStr Nucleated red blood cells explain most of the association between DNA methylation and gestational age
title_full_unstemmed Nucleated red blood cells explain most of the association between DNA methylation and gestational age
title_short Nucleated red blood cells explain most of the association between DNA methylation and gestational age
title_sort nucleated red blood cells explain most of the association between dna methylation and gestational age
url https://doi.org/10.1038/s42003-023-04584-w
work_keys_str_mv AT kristinelhaftorn nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT williamrpdenault nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT yunsunglee nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT christianmpage nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT juliaromanowska nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT robertlyle nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT øyvindenæss nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT danakristjansson nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT permmagnus nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT siriehaberg nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT jonbohlin nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage
AT astanandjugessur nucleatedredbloodcellsexplainmostoftheassociationbetweendnamethylationandgestationalage