Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer
The continuous development of high-throughput and single-cell sequencing technologies and the emergence of spatial transcriptome sequencing have allowed the continuous discovery of temporal and spatial molecular events in the progression of colorectal cancer (CRC) to better understand its mechanism...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2023-06-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1242 |
| _version_ | 1797751786190143488 |
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| author | ZHOU Xiong HU Ming JIANG Dongming CAO Guangwen TAN Xiaojie |
| author_facet | ZHOU Xiong HU Ming JIANG Dongming CAO Guangwen TAN Xiaojie |
| author_sort | ZHOU Xiong |
| collection | DOAJ |
| description | The continuous development of high-throughput and single-cell sequencing technologies and the emergence of spatial transcriptome sequencing have allowed the continuous discovery of temporal and spatial molecular events in the progression of colorectal cancer (CRC) to better understand its mechanism of malignant progression. Genetic variations (mutation of APC and P53, etc.) and mismatch repair of DNA, posttranscriptional regulation, such as epigenetic alteration, and dynamic alteration of complex molecular networks have their own special molecules that play key roles. Drug resistance and metastasis in the late stage of CRC progression are closely related to these key molecular events. This article reviews the research progress and explores key molecular events in the malignant progression of CRC to provide scientific basis and ideas for elucidating the regulatory mechanism of CRC and evaluating its prognosis prediction and treatment. |
| first_indexed | 2024-03-12T16:54:39Z |
| format | Article |
| id | doaj.art-685de654c1be49b09858b0c42039c4ed |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-12T16:54:39Z |
| publishDate | 2023-06-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-685de654c1be49b09858b0c42039c4ed2023-08-08T10:30:41ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-06-0150660961510.3971/j.issn.1000-8578.2023.22.12428578.2023.22.1242Research Progress of Key Molecular Events Related to Progression of Colorectal CancerZHOU Xiong0HU Ming1JIANG Dongming2CAO Guangwen3TAN Xiaojie4Department of Epidemiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, ChinaDepartment of Epidemiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, ChinaTongji University School of Medicine, Shanghai 200092, ChinaDepartment of Epidemiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, ChinaDepartment of Epidemiology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, ChinaThe continuous development of high-throughput and single-cell sequencing technologies and the emergence of spatial transcriptome sequencing have allowed the continuous discovery of temporal and spatial molecular events in the progression of colorectal cancer (CRC) to better understand its mechanism of malignant progression. Genetic variations (mutation of APC and P53, etc.) and mismatch repair of DNA, posttranscriptional regulation, such as epigenetic alteration, and dynamic alteration of complex molecular networks have their own special molecules that play key roles. Drug resistance and metastasis in the late stage of CRC progression are closely related to these key molecular events. This article reviews the research progress and explores key molecular events in the malignant progression of CRC to provide scientific basis and ideas for elucidating the regulatory mechanism of CRC and evaluating its prognosis prediction and treatment.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1242colorectal cancermalignant progressiongenetic variationmolecular events |
| spellingShingle | ZHOU Xiong HU Ming JIANG Dongming CAO Guangwen TAN Xiaojie Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer Zhongliu Fangzhi Yanjiu colorectal cancer malignant progression genetic variation molecular events |
| title | Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer |
| title_full | Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer |
| title_fullStr | Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer |
| title_full_unstemmed | Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer |
| title_short | Research Progress of Key Molecular Events Related to Progression of Colorectal Cancer |
| title_sort | research progress of key molecular events related to progression of colorectal cancer |
| topic | colorectal cancer malignant progression genetic variation molecular events |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1242 |
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