Co-treatment With Everolimus, an mTOR-Specific Antagonist, or Downregulation of ELK1 Enhances the Sensitivity of Pancreatic Cancer Cells to Genistein

Co-treatment With Everolimus, an mTOR-Specific Antagonist, or Downregulation of ELK1 Enhances the Sensitivity of Pancreatic Cancer Cells to Genistein

Genistein is a natural isoflavone with pharmacological or potentially anti-tumor properties. However, the resistance of cancer cells to genistein remains a major obstacle. This study focused on the mechanism implicated in the resistance of pancreatic cancer (PC) cells to genistein and the mechanism...

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Bibliographic Details
Main Authors: Tianyu Li, Tiantao Kuang, Zhaoshuo Yang, Qiqi Zhang, Wen Zhang, Yue Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pancreatic cancer
genistein
Elk1
DEPTOR
mTOR
everolimus
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.633035/full

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