Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats
Abstract Background Adaptive thermogenesis by brown adipose tissue (BAT) is important to the maintenance of temperature in newborn mammals. Cold exposure activates gene expression and lipid metabolism to provide energy for BAT thermogenesis. However, knowledge of BAT metabolism in large animals afte...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Genomics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12864-022-08765-5 |
| _version_ | 1818192819581353984 |
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| author | Xin Liu Jing Tang Runan Zhang Siyuan Zhan Tao Zhong Jiazhong Guo Yan Wang Jiaxue Cao Li Li Hongping Zhang Linjie Wang |
| author_facet | Xin Liu Jing Tang Runan Zhang Siyuan Zhan Tao Zhong Jiazhong Guo Yan Wang Jiaxue Cao Li Li Hongping Zhang Linjie Wang |
| author_sort | Xin Liu |
| collection | DOAJ |
| description | Abstract Background Adaptive thermogenesis by brown adipose tissue (BAT) is important to the maintenance of temperature in newborn mammals. Cold exposure activates gene expression and lipid metabolism to provide energy for BAT thermogenesis. However, knowledge of BAT metabolism in large animals after cold exposure is still limited. Results In this study, we found that cold exposure induced expression of BAT thermogenesis genes and increased the protein levels of UCP1 and PGC1α. Pathway analysis showed that cold exposure activated BAT metabolism, which involved in cGMP-PKG, TCA cycle, fatty acid elongation, and degradation pathways. These were accompanied by decreased triglyceride (TG) content and increased phosphatidylcholine (PC) and phosphatidylethanolamine (PE) content in BAT. Conclusion These results demonstrate that cold exposure induces metabolites involved in glycerolipids and glycerophospholipids metabolism in BAT. The present study provides evidence for lipid composition associated with adaptive thermogenesis in goat BAT and metabolism pathways regulated by cold exposure. |
| first_indexed | 2024-12-12T00:36:34Z |
| format | Article |
| id | doaj.art-685e75b57d774bfcb8c0c60261196059 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-12T00:36:34Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-685e75b57d774bfcb8c0c602611960592022-12-22T00:44:21ZengBMCBMC Genomics1471-21642022-07-0123111210.1186/s12864-022-08765-5Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goatsXin Liu0Jing Tang1Runan Zhang2Siyuan Zhan3Tao Zhong4Jiazhong Guo5Yan Wang6Jiaxue Cao7Li Li8Hongping Zhang9Linjie Wang10Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityCollege of Animal Science and Technology, Sichuan Agricultural UniversityCollege of Animal Science and Technology, Sichuan Agricultural UniversityCollege of Animal Science and Technology, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityCollege of Animal Science and Technology, Sichuan Agricultural UniversityFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural UniversityAbstract Background Adaptive thermogenesis by brown adipose tissue (BAT) is important to the maintenance of temperature in newborn mammals. Cold exposure activates gene expression and lipid metabolism to provide energy for BAT thermogenesis. However, knowledge of BAT metabolism in large animals after cold exposure is still limited. Results In this study, we found that cold exposure induced expression of BAT thermogenesis genes and increased the protein levels of UCP1 and PGC1α. Pathway analysis showed that cold exposure activated BAT metabolism, which involved in cGMP-PKG, TCA cycle, fatty acid elongation, and degradation pathways. These were accompanied by decreased triglyceride (TG) content and increased phosphatidylcholine (PC) and phosphatidylethanolamine (PE) content in BAT. Conclusion These results demonstrate that cold exposure induces metabolites involved in glycerolipids and glycerophospholipids metabolism in BAT. The present study provides evidence for lipid composition associated with adaptive thermogenesis in goat BAT and metabolism pathways regulated by cold exposure.https://doi.org/10.1186/s12864-022-08765-5Brown adipose tissueCold exposureLipid metabolismRNA-seqThermogenesis |
| spellingShingle | Xin Liu Jing Tang Runan Zhang Siyuan Zhan Tao Zhong Jiazhong Guo Yan Wang Jiaxue Cao Li Li Hongping Zhang Linjie Wang Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats BMC Genomics Brown adipose tissue Cold exposure Lipid metabolism RNA-seq Thermogenesis |
| title | Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats |
| title_full | Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats |
| title_fullStr | Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats |
| title_full_unstemmed | Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats |
| title_short | Cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats |
| title_sort | cold exposure induces lipid dynamics and thermogenesis in brown adipose tissue of goats |
| topic | Brown adipose tissue Cold exposure Lipid metabolism RNA-seq Thermogenesis |
| url | https://doi.org/10.1186/s12864-022-08765-5 |
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