Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor signalling - which could be targeted with MEK/EGFR inhi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35134-3 |
| _version_ | 1811179128622153728 |
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| author | Dustin J. Flanagan Raheleh Amirkhah David F. Vincent Nuray Gundaz Pauline Gentaz Patrizia Cammareri Aoife J. McCooey Amy M. B. McCorry Natalie C. Fisher Hayley L. Davis Rachel A. Ridgway Jeroen Lohuis Joshua D. G. Leach Rene Jackstadt Kathryn Gilroy Elisa Mariella Colin Nixon William Clark Ann Hedley Elke K. Markert Douglas Strathdee Laurent Bartholin Keara L. Redmond Emma M. Kerr Daniel B. Longley Fiona Ginty Sanghee Cho Helen G. Coleman Maurice B. Loughrey Alberto Bardelli Timothy S. Maughan Andrew D. Campbell Mark Lawler Simon J. Leedham Simon T. Barry Gareth J. Inman Jacco van Rheenen Philip D. Dunne Owen J. Sansom |
| author_facet | Dustin J. Flanagan Raheleh Amirkhah David F. Vincent Nuray Gundaz Pauline Gentaz Patrizia Cammareri Aoife J. McCooey Amy M. B. McCorry Natalie C. Fisher Hayley L. Davis Rachel A. Ridgway Jeroen Lohuis Joshua D. G. Leach Rene Jackstadt Kathryn Gilroy Elisa Mariella Colin Nixon William Clark Ann Hedley Elke K. Markert Douglas Strathdee Laurent Bartholin Keara L. Redmond Emma M. Kerr Daniel B. Longley Fiona Ginty Sanghee Cho Helen G. Coleman Maurice B. Loughrey Alberto Bardelli Timothy S. Maughan Andrew D. Campbell Mark Lawler Simon J. Leedham Simon T. Barry Gareth J. Inman Jacco van Rheenen Philip D. Dunne Owen J. Sansom |
| author_sort | Dustin J. Flanagan |
| collection | DOAJ |
| description | It remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor signalling - which could be targeted with MEK/EGFR inhibitors. |
| first_indexed | 2024-04-11T06:30:35Z |
| format | Article |
| id | doaj.art-685f337608c24440b7e084866104173a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T06:30:35Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-685f337608c24440b7e084866104173a2022-12-22T04:40:06ZengNature PortfolioNature Communications2041-17232022-12-0113111810.1038/s41467-022-35134-3Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive featuresDustin J. Flanagan0Raheleh Amirkhah1David F. Vincent2Nuray Gundaz3Pauline Gentaz4Patrizia Cammareri5Aoife J. McCooey6Amy M. B. McCorry7Natalie C. Fisher8Hayley L. Davis9Rachel A. Ridgway10Jeroen Lohuis11Joshua D. G. Leach12Rene Jackstadt13Kathryn Gilroy14Elisa Mariella15Colin Nixon16William Clark17Ann Hedley18Elke K. Markert19Douglas Strathdee20Laurent Bartholin21Keara L. Redmond22Emma M. Kerr23Daniel B. Longley24Fiona Ginty25Sanghee Cho26Helen G. Coleman27Maurice B. Loughrey28Alberto Bardelli29Timothy S. Maughan30Andrew D. Campbell31Mark Lawler32Simon J. Leedham33Simon T. Barry34Gareth J. Inman35Jacco van Rheenen36Philip D. Dunne37Owen J. Sansom38Cancer Research UK Beatson InstituteThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastWellcome Trust Centre for Human Genetics, University of OxfordCancer Research UK Beatson InstituteDepartment of Molecular Pathology, Oncode Institute, The Netherlands Cancer InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteDepartment of Oncology, University of TorinoCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteINSERM Centre de Recherche en Cancérologie de LyonThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastGE Global Research CenterGE Global Research CenterThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastDepartment of Oncology, University of TorinoCRUK/MRC Oxford Institute for Radiation Oncology, University of OxfordCancer Research UK Beatson InstituteThe Patrick G. Johnston Centre for Cancer Research, Queen’s University BelfastWellcome Trust Centre for Human Genetics, University of OxfordBioscience, Oncology R&D, AstraZenecaCancer Research UK Beatson InstituteDepartment of Molecular Pathology, Oncode Institute, The Netherlands Cancer InstituteCancer Research UK Beatson InstituteCancer Research UK Beatson InstituteIt remains critical to identify colorectal cancers (CRC) that will disseminate as early as possible. Here, the authors identify CRC tumours that are aggressive and prone to early dissemination, characterised by epithelial TGFβ and growth-factor signalling - which could be targeted with MEK/EGFR inhibitors.https://doi.org/10.1038/s41467-022-35134-3 |
| spellingShingle | Dustin J. Flanagan Raheleh Amirkhah David F. Vincent Nuray Gundaz Pauline Gentaz Patrizia Cammareri Aoife J. McCooey Amy M. B. McCorry Natalie C. Fisher Hayley L. Davis Rachel A. Ridgway Jeroen Lohuis Joshua D. G. Leach Rene Jackstadt Kathryn Gilroy Elisa Mariella Colin Nixon William Clark Ann Hedley Elke K. Markert Douglas Strathdee Laurent Bartholin Keara L. Redmond Emma M. Kerr Daniel B. Longley Fiona Ginty Sanghee Cho Helen G. Coleman Maurice B. Loughrey Alberto Bardelli Timothy S. Maughan Andrew D. Campbell Mark Lawler Simon J. Leedham Simon T. Barry Gareth J. Inman Jacco van Rheenen Philip D. Dunne Owen J. Sansom Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features Nature Communications |
| title | Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features |
| title_full | Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features |
| title_fullStr | Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features |
| title_full_unstemmed | Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features |
| title_short | Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features |
| title_sort | epithelial tgfβ engages growth factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features |
| url | https://doi.org/10.1038/s41467-022-35134-3 |
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