Insertion/deletion polymorphisms in the ΔNp63 promoter are a risk factor for bladder exstrophy epispadias complex.
Bladder exstrophy epispadias complex (BEEC) is a severe congenital anomaly; however, the genetic and molecular mechanisms underlying the formation of BEEC remain unclear. TP63, a member of TP53 tumor suppressor gene family, is expressed in bladder urothelium and skin over the external genitalia duri...
Main Authors: | Simon Wilkins, Ke Wei Zhang, Istiak Mahfuz, Renaud Quantin, Nancy D'Cruz, John Hutson, Michael Ee, Darius Bagli, Karen Aitken, Fion Nga-Yin Fong, Patrick Kwok-Shing Ng, Stephen Kwok-Wing Tsui, Wendy Yin-Wan Fung, Tahmina Banu, Atul Thakre, Kaid Johar, Enrique Jaureguizar, Long Li, Wei Cheng |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3527294?pdf=render |
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